24284-35-3

Upstream product

• 108-86-1 bromobenzene 
• 17630-76-1 5-chloroindole 2,3-dione 
• 841-76-9 triphenylaluminium 
• 23746-76-1 5-chloro-2-phenylindole 
• 1417819-68-1 1-azido-4-chloro-2-(phenylethynyl)benzene 
• 100-58-3 phenylmagnesium bromide 
• 98-80-6 phenylboronic acid 

Downstream Products

• 24279-55-8 2-amino-5-chloro-3-hydroxy-3-phenylindole 
• 1243153-56-1 C₃₂H₂₅ClN₂OSi 
• 1243153-55-0 N-allyl-5-chloro-3-hydroxy-3-phenylindol-2-amine 
• 1399290-75-5 tert-butyl 5-chloro-2-oxo-3-phenylindoline-1-carboxylate 
• 719-59-5 5-chloro-2-aminobenzophenone 
• 1243153-75-4 (S)-2-amino-5-chloro-3-hydroxy-3-phenylindole 
• 1243153-73-2 (S)-5-chloro-3-hydroxy-3-phenylindolin-2-one 
• 15815-97-1 5-chloro-3-phenyl-2-indolinone 
• 77014-77-8 5-Chloro-1-(4-chloro-benzoyl)-3-imidazol-1-yl-3-phenyl-1,3-dihydro-indol-2-one 
• 77014-75-6 1-Benzoyl-5-chloro-3-imidazol-1-yl-3-phenyl-1,3-dihydro-indol-2-one 
• 77015-03-3 1-Acetyl-5-chloro-3-imidazol-1-yl-3-phenyl-1,3-dihydro-indol-2-one 

Relevant academic research and scientific papers

One-Pot Synthesis of 2-Aminobenzophenones from 2-Alkynyl Arylazides Catalyzed by Pd and Cu Precursors

We describe a novel one-pot three-step reaction of 2-alkynyl arylazides through palladium-catalyzed formation of 3-hydroxy-3-phenylindolin-2-ones followed by hydrolysis of amide bonds and copper-catalyzed decarboxylation to give 2-aminobenzophenones. This synthetic method works well with various 2-alkynyl arylazides and affords the products in moderate to good yields under mild reaction conditions.

One-pot synthesis of 3-hydroxy-2-oxindoles: Via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides

A novel one-pot method to prepare 3-hydroxy-2-oxindoles via acyloin rearrangements of 2-hydroxy-indolin-3-ones generated in situ from 2-alkynyl arylazides has been described. The reaction was accomplished to afford a variety of 3-hydroxy-2-oxindole derivatives in moderate to good yields under mild conditions. This journal is

Preparation process of 3-peroxy-2-indolone compound in water phase

The invention relates to a preparation process of a 3-peroxy-2-indolone compound. The method comprises the steps of adopting a 2-indolone derivative as a raw material and water as a reaction solvent for a reaction with tert-butanol peroxide at a certain t

C(sp 3)-H Peroxidation of 3-Substituted Indolin-2-ones under Metal-Free Conditions

A C(sp 3)-H peroxidation of 3-substituted indolin-2-ones through radical coupling reaction has been developed under metal-free conditions. Using tert -butyl hydroperoxide both as an oxidant and as a peroxidation reagent to couple with the C(sp 3)-H bonds of 3-substituted indolin-2-ones can form a new C-O bond without using any additives. This simple strategy provides a green and efficient approach to 3-peroxyindolin-2-ones in moderate to excellent yields. The resulting 3-peroxyindolin-2-ones could be further transformed into 3-hydroxyindolin-2-ones.

Organocatalytic stereoselective conjugate addition of 3-substituted oxindoles with in situ generated ortho-quinone methides

A novel method for the stereoselective conjugate addition of 3-substituted oxindoles to in situ generated o-QMs was described. This process was catalyzed efficiently by a cinchonidine-derived squaramide catalyst in oil-water phase, furnishing the corresponding 3,3-disubsituted oxindole derivatives in moderate to high yields (up to 98%) with high stereoselectivities (up to 95% ee, 15.4:1 dr). The utility of this reaction was also investigated by the gram-scale synthesis and derivatization of one of the products.

Catalyst-free synthesis of 3-hydroxy-3-(alkyl/aryl)indolin-2-ones by addition of organoaluminum reagents to isatins

An efficient synthesis of 3-hydroxy-3-(alkyl/aryl)indol-2-one derivatives has been described by the reactions of isatin with organoaluminum reagents. The reaction is very rapid and yields are high. The protocol is applicable for substituted isatins as well as a variety of organoaluminums.

2-AMINOINDOLE COMPOUNDS AND METHODS FOR THE TREATMENT OF MALARIA

The present invention relates to methods of treating a subject with malaria comprising administering a 2-aminoindole compound represented by Formula: (I)- The values and preferred values of the variables in Structural Formula I are defined herein.

A concise silylamine approach to 2-amino-3-hydroxy-indoles with potent in vivo antimalaria activity

The development of a concise strategy to access 2-amino-3-hydroxy-indoles, which are disclosed as novel antimalarials with potent in vivo activity, is reported. Starting from isatins the target compounds are synthesized in 2 steps and in good yields via oxoindole intermediates by employing tert- butyldimethylsilyl amine (TBDMSNH2) as previously unexplored ammonia equivalent.

Rhodium-catalyzed addition of arylboronic acids to isatins: An entry to diversity in 3-aryl-3-hydroxyoxindoles

A general method for the catalytic 1,2-addition of aryl and alkenyl boronic acids to isatins is described using a rhodium(I)/triphenylphosphite catalyst. The application of this transformation allows the synthesis of a variety of 3-aryl-3-hydroxyoxindole