4,5-dimethoxy-N,2-dimethylaniline

Base Information

• Chemical Name: 4,5-dimethoxy-N,2-dimethylaniline
• CAS No.: 408509-80-8
• Molecular Formula: C₁₀H₁₅NO₂
• Molecular Weight: 181.235
• Mol file: 408509-80-8.mol

Synonyms:4,5-dimethoxy-N,2-dimethylaniline

Chemical Property of 4,5-dimethoxy-N,2-dimethylaniline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4,5-dimethoxy-N,2-dimethylaniline

There total 4 articles about 4,5-dimethoxy-N,2-dimethylaniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

2-tert-Butoxycarbonylamino-4,5-dimethoxy-benzoic acid (122744-78-9) → 4,5-dimethoxy-N,2-dimethylaniline (408509-80-8)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; Reflux;

DOI:10.1039/c2nj40567a

Reference yield:

2-Amino-4,5-dimethoxybenzoic acid (5653-40-7) → 4,5-dimethoxy-N,2-dimethylaniline (408509-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: methanol / 24 h / 20 °C

2: lithium aluminium tetrahydride / tetrahydrofuran / 0 °C / Reflux

With lithium aluminium tetrahydride; In tetrahydrofuran; methanol;

DOI:10.1039/c2nj40567a

Reference yield:

1,2-dimethoxy-4-methyl-5-nitrobenzene (7509-11-7) → 4,5-dimethoxy-N,2-dimethylaniline (408509-80-8)

Guidance literature:

Multi-step reaction with 2 steps

1: Raney nickel; ethanol / 60 - 65 °C / Hydrogenation

2: water; sodium acetate; Raney nickel / Hydrogenation_.Reagens 4: Aethanol

With ethanol; water; sodium acetate; nickel;

DOI:10.1002/hlca.19560390112

upstream raw materials:

formaldehyd

4,5-dimethoxy-2-methylaniline

1,2-dimethoxy-4-methyl-5-nitrobenzene

2-tert-Butoxycarbonylamino-4,5-dimethoxy-benzoic acid