N-(4-phenylbutyl)picolinamide

Base Information

• Chemical Name: N-(4-phenylbutyl)picolinamide
• CAS No.: 1443771-36-5
• Molecular Formula: C₁₆H₁₈N₂O
• Molecular Weight: 254.332
• Mol file: 1443771-36-5.mol

Synonyms:N-(4-phenylbutyl)picolinamide

Chemical Property of N-(4-phenylbutyl)picolinamide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-phenylbutyl)picolinamide

There total 1 articles about N-(4-phenylbutyl)picolinamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

2-Picolinic acid (98-98-6) + 4-phenyl-1-butylamine (13214-66-9) → N-(4-phenylbutyl)picolinamide (1443771-36-5)

Guidance literature:

With N-ethyl-N,N-diisopropylamine; N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.05.068

Reference yield: 96.0%

N-(4-phenylbutyl)picolinamide (1443771-36-5) → 4-phenyl-1-butylamine (13214-66-9)

Guidance literature:

N-(4-phenylbutyl)picolinamide; With hydrogenchloride; In water; at 20 ℃; for 0.0833333h; Inert atmosphere;

With zinc; In water; at 20 ℃; for 16h; Inert atmosphere;

DOI:10.1016/j.tetlet.2016.05.068

Reference yield:

N-(4-phenylbutyl)picolinamide (1443771-36-5) → C16H17IN2O (1443771-47-8) + C16H17IN2O (1443771-48-9)

Guidance literature:

With tetrafluoroboric acid diethyl ether; N-iodo-succinimide; In dichloromethane; trifluoroacetic acid; at 0 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ol4015078

upstream raw materials:

2-Picolinic acid

4-phenyl-1-butylamine

Downstream raw materials:

C₁₆H₁₇IN₂O

C₁₆H₁₇IN₂O

4-phenyl-1-butylamine