Technology Process of 3-(2-fluorophenyl)-2-(methoxycarbonyl)-6H-benzo[c]chromene-8-carboxylic acid
There total 14 articles about 3-(2-fluorophenyl)-2-(methoxycarbonyl)-6H-benzo[c]chromene-8-carboxylic acid which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine;
In
water; N,N-dimethyl-formamide;
at 80 ℃;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: iron; acetic acid / 2 h / 85 °C
2.1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
3.2: 1 h / 20 °C
4.1: tetrafluoroboric acid; N,N-dimethyl acetamide; palladium diacetate; potassium carbonate; tricyclohexylphosphine / 100 °C / Inert atmosphere
5.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere
6.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
7.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / water; N,N-dimethyl-formamide / 80 °C
With
aluminum (III) chloride; tetrafluoroboric acid; N,N-dimethyl acetamide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; water; palladium diacetate; iron; sodium hydride; potassium carbonate; acetic acid; triethylamine; sodium nitrite; tricyclohexylphosphine;
In
dichloromethane; water; N,N-dimethyl-formamide;
4.1: |Sonogashira Cross-Coupling;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: sulfuric acid; water; sodium nitrite / 19 h / 0 - 60 °C
2.1: sodium hydride / N,N-dimethyl-formamide / 0.5 h / 0 °C / Inert atmosphere
2.2: 1 h / 20 °C
3.1: tetrafluoroboric acid; N,N-dimethyl acetamide; palladium diacetate; potassium carbonate; tricyclohexylphosphine / 100 °C / Inert atmosphere
4.1: aluminum (III) chloride / dichloromethane / 1 h / 0 °C / Inert atmosphere
5.1: triethylamine / dichloromethane / 1 h / 0 - 20 °C
6.1: 1,3-bis-(diphenylphosphino)propane; palladium diacetate; triethylamine / water; N,N-dimethyl-formamide / 80 °C
With
aluminum (III) chloride; tetrafluoroboric acid; N,N-dimethyl acetamide; sulfuric acid; 1,3-bis-(diphenylphosphino)propane; water; palladium diacetate; sodium hydride; potassium carbonate; triethylamine; sodium nitrite; tricyclohexylphosphine;
In
dichloromethane; water; N,N-dimethyl-formamide;
3.1: |Sonogashira Cross-Coupling;
