(2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate

Base Information

Chemical Name:(2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate
CAS No.:246028-23-9
Molecular Formula:C₁₉H₂₉F₂O₄PS
Molecular Weight:422.473
Hs Code.:

Synonyms:(2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate

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Chemical Property of (2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate

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Technology Process of (2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate

There total 4 articles about (2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 246028-17-1
(2S,R_S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfinyl)-hept-5-enylphosphonate

: 246028-23-9
(2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate

Guidance literature:: With trifluoroacetic anhydride; sodium iodide; In acetone; at -20 ℃; for 0.166667h;
DOI:10.1002/(sici)1099-0690(199909)1999:9<2149::aid-ejoc2149>3.0.co;2-d

Reference yield:

: 17843-01-5
diethyl (ethoxycarbonyl)(difluoromethyl)phosphonate

: 246028-23-9
(2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran / 0.03 h / -70 °C

2: NaBH₄ / methanol; aq. NH₃ / 0.17 h / 0 °C

3: 87 percent / trifluoroacetic anhydride; NaI / acetone / 0.17 h / -20 °C

With sodium tetrahydroborate; trifluoroacetic anhydride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ammonium hydroxide; acetone; 1: Condensation / 2: Hydrogenation / 3: deoxygenation;
DOI:10.1002/(sici)1099-0690(199909)1999:9<2149::aid-ejoc2149>3.0.co;2-d

Reference yield:

: 115878-99-4
(R)-1-<(4-methylphenyl)sulphinyl>-4-methyl-3-pentene

: 246028-23-9
(2S)-diethyl 1,1-difluoro-2-hydroxy-6-methyl-3-(4-methylphenylsulfenyl)-hept-5-enylphosphonate

Guidance literature:: Multi-step reaction with 3 steps

1: LDA / tetrahydrofuran / 0.03 h / -70 °C

2: NaBH₄ / methanol; aq. NH₃ / 0.17 h / 0 °C

3: 87 percent / trifluoroacetic anhydride; NaI / acetone / 0.17 h / -20 °C

With sodium tetrahydroborate; trifluoroacetic anhydride; sodium iodide; lithium diisopropyl amide; In tetrahydrofuran; methanol; ammonium hydroxide; acetone; 1: Condensation / 2: Hydrogenation / 3: deoxygenation;
DOI:10.1002/(sici)1099-0690(199909)1999:9<2149::aid-ejoc2149>3.0.co;2-d