Difluoro(diethoxyphosphinyl)acetic acid ethyl ester

Base Information

Chemical Name:Difluoro(diethoxyphosphinyl)acetic acid ethyl ester
CAS No.:17843-01-5
Molecular Formula:C₈H₁₅F₂O₅P
Molecular Weight:260.175
Hs Code.:2931900090
DSSTox Substance ID:DTXSID20939080
Nikkaji Number:J933.346K
Wikidata:Q82915515
Mol file:17843-01-5.mol

Synonyms:17843-01-5;Difluoro(diethoxyphosphinyl)acetic acid ethyl ester;Ethyl 2-diethoxyphosphoryl-2,2-difluoroacetate;SCHEMBL16761029;DTXSID20939080;QCFJPVUGEBJHPE-UHFFFAOYSA-N;Triethyl 2,2-Difluorophosphonoacetate;Ethyl (diethoxyphosphoryl)(difluoro)acetate;(Diethoxy-phosphoryl)-difluoro-acetic acid ethyl ester

Suppliers and Price of Difluoro(diethoxyphosphinyl)acetic acid ethyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 5 raw suppliers

Chemical Property of Difluoro(diethoxyphosphinyl)acetic acid ethyl ester

Chemical Property:

PSA：71.64000
LogP:2.40840
XLogP3:1.2
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:7
Rotatable Bond Count:8
Exact Mass:260.06251690
Heavy Atom Count:16
Complexity:272

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CCOC(=O)C(F)(F)P(=O)(OCC)OCC

Technology Process of Difluoro(diethoxyphosphinyl)acetic acid ethyl ester

There total 8 articles about Difluoro(diethoxyphosphinyl)acetic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 69.0%

: 867-13-0
diethoxyphosphoryl-acetic acid ethyl ester

: 17843-01-5
diethyl (ethoxycarbonyl)(difluoromethyl)phosphonate

Guidance literature:: diethoxyphosphoryl-acetic acid ethyl ester; With sodium hydride; In tetrahydrofuran; at 0 - 20 ℃; for 2h;

With Selectfluor; In tetrahydrofuran; at 0 - 20 ℃; for 4h;
DOI:10.1016/j.jfluchem.2005.04.002

Reference yield: 60.0%

: 2356-16-3
ethyl(diethylphosphono)(fluoro)acetate

: 17843-01-5
diethyl (ethoxycarbonyl)(difluoromethyl)phosphonate

Guidance literature:: With sodium hydride; Selectfluor; In tetrahydrofuran; 1.) 0 deg C, 15 min, 2.) DMF, r.t., 3 d;
DOI:10.1055/s-1998-4501

Reference yield: 53.0%

: 541-41-3
chloroformic acid ethyl ester

: 82845-20-3
[(diethoxyphosphoryl)difluoromethyl]zinc bromide

: 17843-01-5
diethyl (ethoxycarbonyl)(difluoromethyl)phosphonate

Guidance literature:: With copper(I) bromide; In 1,2-dimethoxyethane; acetonitrile; for 0.5h; Ambient temperature;
DOI:10.1080/10426509708043514