3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

Base Information

Chemical Name:3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester
CAS No.:1035217-21-0
Molecular Formula:C₁₆H₁₇N₃O₄
Molecular Weight:315.329
Hs Code.:

Synonyms:3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

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Chemical Property of 3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

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Technology Process of 3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

There total 2 articles about 3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1035217-20-9
2-iodo-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid benzyl ester

: 124-38-9,18923-20-1
carbon dioxide

: 1035217-21-0
3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

Guidance literature:: 2-iodo-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid benzyl ester; With ethylmagnesium bromide; In tetrahydrofuran; at 0 - 2.5 ℃; for 0.25h;

carbon dioxide; In tetrahydrofuran;

With acetic acid; In tetrahydrofuran; ethyl acetate; at 20 ℃; for 0.25h;

Reference yield:

: 1035217-19-6
3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid benzyl ester

: 1035217-21-0
3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

Guidance literature:: Multi-step reaction with 2 steps

1.1: N-iodo-succinimide / 1,2-dichloro-ethane / 1 h / Reflux

2.1: ethylmagnesium bromide / tetrahydrofuran / 0.25 h / 0 - 2.5 °C / Inert atmosphere

2.2: Inert atmosphere

2.3: 0.25 h / 20 °C

With N-iodo-succinimide; ethylmagnesium bromide; In tetrahydrofuran; 1,2-dichloro-ethane;

Reference yield: 29.0%

: 1035216-81-9,1035218-35-9
(E)-3-chloro-N'-hydroxy-4-isopropoxybenzimidamide

: 1035217-21-0
3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

: 1035216-14-8
2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid benzyl ester

Guidance literature:: 3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester; With oxalyl dichloride; N,N-dimethyl-formamide; In dichloromethane; for 1h;

(E)-3-chloro-N'-hydroxy-4-isopropoxybenzimidamide; With pyridine; at 115 ℃; for 4h;