1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone

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Chemical Name:1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone
CAS No.:1035216-18-2
Molecular Formula:C₂₀H₂₂ClN₅O₃
Molecular Weight:415.879
Hs Code.:

Synonyms:1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone

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Chemical Property of 1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone

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Technology Process of 1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone

There total 6 articles about 1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1035216-16-0
2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6,7,8-tetrahydro-imidazo[1,2-a]pyrazine

: 75-36-5
acetyl chloride

: 1035216-18-2
1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone

Guidance literature:: In dichloromethane; at 20 ℃; for 4h;

Reference yield:

: 1035217-20-9
2-iodo-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-7-carboxylic acid benzyl ester

: 1035216-18-2
1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone

Guidance literature:: Multi-step reaction with 5 steps

1.1: ethylmagnesium bromide / tetrahydrofuran / 0.25 h / 0 - 2.5 °C / Inert atmosphere

1.2: Inert atmosphere

1.3: 0.25 h / 20 °C

2.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

3.1: pyridine / 0.5 h / 20 °C

3.2: 4 h / 115 °C / Inert atmosphere

4.1: chlorotriisopropylsilane; hydrogen bromide; acetic acid / 0.17 h / 20 °C / Inert atmosphere

5.1: dichloromethane / 4 h / 20 °C

With pyridine; oxalyl dichloride; chlorotriisopropylsilane; ethylmagnesium bromide; hydrogen bromide; acetic acid; N,N-dimethyl-formamide; In tetrahydrofuran; dichloromethane;

Reference yield:

: 1035217-21-0
3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazine-2,7-dicarboxylic acid 7-benzyl ester

: 1035216-18-2
1-{2-[3-(3-chloro-4-isopropoxy-phenyl)-[1,2,4]oxadiazol-5-yl]-3-methyl-5,6-dihydro-8H-imidazo[1,2-a]pyrazin-7-yl}-ethanone

Guidance literature:: Multi-step reaction with 4 steps

1.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 1 h

2.1: pyridine / 0.5 h / 20 °C

2.2: 4 h / 115 °C / Inert atmosphere

3.1: chlorotriisopropylsilane; hydrogen bromide; acetic acid / 0.17 h / 20 °C / Inert atmosphere

4.1: dichloromethane / 4 h / 20 °C

With pyridine; oxalyl dichloride; chlorotriisopropylsilane; hydrogen bromide; acetic acid; N,N-dimethyl-formamide; In dichloromethane;