tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate

Base Information

Chemical Name:tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate
CAS No.:410092-72-7
Molecular Formula:C₁₅H₂₈O₇P₂Si
Molecular Weight:410.416
Hs Code.:

Synonyms:tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate

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Chemical Property of tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate

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Technology Process of tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate

There total 8 articles about tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 868-85-9
Dimethyl phosphite

: dimethyl m-trimethylsilylphenylacetylphosphonate

: 410092-72-7
tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate

Guidance literature:: With dibutylamine; In diethyl ether; hexane; for 0.333333h;
DOI:10.1021/jm021107v

Reference yield:

: 410092-71-6
dimethyl m-trimethylsilylphenylacetylphosphonate

: 96-36-6,868-85-9
methyl phosphite

: 111-92-2
dibutylamine

: 410092-72-7
tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate

Guidance literature:: In diethyl ether; hexane;

Reference yield:

: 108-41-8
1-chloro-3-methylbenzene

: 410092-72-7
tetramethyl 1-hydroxy(m-trimethylsilylphenyl)ethylidene-1,1-bisphosphonate

Guidance literature:: Multi-step reaction with 7 steps

1.1: Mg; 1,2-dibromoethane / tetrahydrofuran / 4 h / Heating

1.2: 92 percent / tetrahydrofuran

2.1: 99 percent / NBS; 2,2'-azobis(isobutyronitrile) / chlorobenzene / 80 - 90 °C

3.1: 55 percent / tributylamine / H₂O

4.1: 94 percent / NaOH / methanol / 4 h / Heating

5.1: SOCl₂ / 20 °C

6.1: tetrahydrofuran / 0.5 h / 0 °C / ultrasound irradiation

7.1: 65 percent / dibutylamine / diethyl ether; hexane / 0.33 h

With sodium hydroxide; N-Bromosuccinimide; thionyl chloride; tributyl-amine; 2,2'-azobis(isobutyronitrile); magnesium; dibutylamine; ethylene dibromide; In tetrahydrofuran; methanol; diethyl ether; hexane; water; chlorobenzene;
DOI:10.1021/jm021107v