rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

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Chemical Name:rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid
CAS No.:1353656-34-4
Molecular Formula:C₂₄H₂₀N₄O₄S
Molecular Weight:460.513
Hs Code.:

Synonyms:rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

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Chemical Property of rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

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Technology Process of rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

There total 5 articles about rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 1353657-64-3
rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

: 1353656-34-4
rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

Guidance literature:: rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate; With lithium hydroxide; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water; pH=4;

Reference yield:

: 586-42-5
3-acetylbenzoic acid

: 1353656-34-4
rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; toluene; diethyl ether / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium cyanoborohydride / methanol; water / 20 °C / pH 3

3.1: phosphorus tribromide / toluene / 0.75 h / 0 - 20 °C

4.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

5.1: lithium hydroxide / tetrahydrofuran / 20 °C

5.2: pH 4

With hydrogenchloride; phosphorus tribromide; sodium cyanoborohydride; sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 50603-99-1
methyl 3-(1-bromoethyl)benzoate

: 1353656-34-4
rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 20 °C

2.2: pH 4

With sodium hydrogencarbonate; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;