rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide

Base Information

Chemical Name:rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide
CAS No.:1353656-78-6
Molecular Formula:C₂₅H₂₃N₅O₃S
Molecular Weight:473.555
Hs Code.:

Synonyms:rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide

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Chemical Property of rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide

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Technology Process of rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide

There total 6 articles about rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 1353656-34-4
rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid

: 74-89-5
methylamine

: 1353656-78-6
rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide

Guidance literature:: rac-3-[(1S)-1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylic acid; With HATU; In N,N-dimethyl-formamide; at 0 ℃; for 0.333333h;

methylamine; With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 586-42-5
3-acetylbenzoic acid

: 1353656-78-6
rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: methanol; toluene; diethyl ether / 0.17 h / 20 °C

2.1: hydrogenchloride; sodium cyanoborohydride / methanol; water / 20 °C / pH 3

3.1: phosphorus tribromide / toluene / 0.75 h / 0 - 20 °C

4.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

5.1: lithium hydroxide / tetrahydrofuran / 20 °C

5.2: pH 4

6.1: HATU / N,N-dimethyl-formamide / 0.33 h / 0 °C

6.2: 20 °C

With hydrogenchloride; phosphorus tribromide; sodium cyanoborohydride; sodium hydrogencarbonate; HATU; lithium hydroxide; In tetrahydrofuran; methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 50603-99-1
methyl 3-(1-bromoethyl)benzoate

: 1353656-78-6
rac-3-[1-({6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)ethyl]-N-methylbenzenecarboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

2.1: lithium hydroxide / tetrahydrofuran / 20 °C

2.2: pH 4

3.1: HATU / N,N-dimethyl-formamide / 0.33 h / 0 °C

3.2: 20 °C

With sodium hydrogencarbonate; HATU; lithium hydroxide; In tetrahydrofuran; N,N-dimethyl-formamide;