rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

Base Information

Chemical Name:rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate
CAS No.:1353657-64-3
Molecular Formula:C₂₅H₂₂N₄O₄S
Molecular Weight:474.54
Hs Code.:

Synonyms:rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

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Chemical Property of rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

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Technology Process of rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

There total 4 articles about rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 544417-72-3
2-amino-4-[4-(2-hydroxyethoxy)phenyl]-6-sulfanylpyridine-3,5-dicarbonitrile

: 50603-99-1
methyl 3-(1-bromoethyl)benzoate

: 1353657-64-3
rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

Guidance literature:: With sodium hydrogencarbonate; In N,N-dimethyl-formamide; at 20 ℃;

Reference yield:

: 586-42-5
3-acetylbenzoic acid

: 1353657-64-3
rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: methanol; toluene; diethyl ether / 0.17 h / 20 °C

2: hydrogenchloride; sodium cyanoborohydride / methanol; water / 20 °C / pH 3

3: phosphorus tribromide / toluene / 0.75 h / 0 - 20 °C

4: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

With hydrogenchloride; phosphorus tribromide; sodium cyanoborohydride; sodium hydrogencarbonate; In methanol; diethyl ether; water; N,N-dimethyl-formamide; toluene;

Reference yield:

: 87808-11-5
methyl 3-(1-hydroxyethyl)benzenecarboxylate

: 1353657-64-3
rac-methyl 3-[(1-{6-amino-3,5-dicyano-4-[4-(2-hydroxyethoxy)phenyl]pyridin-2-yl}sulfanyl)-ethyl]benzenecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: phosphorus tribromide / toluene / 0.75 h / 0 - 20 °C

2: sodium hydrogencarbonate / N,N-dimethyl-formamide / 20 °C

With phosphorus tribromide; sodium hydrogencarbonate; In N,N-dimethyl-formamide; toluene;