2-[[(4-Methoxyphenyl)methyl]amino]benzamide

Base Information

• Chemical Name: 2-[[(4-Methoxyphenyl)methyl]amino]benzamide
• CAS No.: 111232-48-5
• Molecular Formula: C₁₅H₁₆N₂O₂
• Molecular Weight: 256.304
• DSSTox Substance ID: DTXSID901261351
• Nikkaji Number: J3.454.945A
• Mol file: 111232-48-5.mol

Synonyms:111232-48-5;SCHEMBL12725545;DTXSID901261351;2-[[(4-Methoxyphenyl)methyl]amino]benzamide

Chemical Property of 2-[[(4-Methoxyphenyl)methyl]amino]benzamide

Chemical Property:

• XLogP3: 2.3
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 256.121177757
• Heavy Atom Count: 19
• Complexity: 288

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CNC2=CC=CC=C2C(=O)N

Technology Process of 2-[[(4-Methoxyphenyl)methyl]amino]benzamide

There total 2 articles about 2-[[(4-Methoxyphenyl)methyl]amino]benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

p-Methoxybenzyl bromide (2746-25-0) + anthranilic acid amide (28144-70-9,88-68-6) → 2-<(4-methoxybenzyl)amino>benzamide (111232-48-5)

Guidance literature:

With potassium carbonate; potassium iodide; In N,N-dimethyl-formamide; for 24h; Ambient temperature;

DOI:10.3987/R-1987-01-0191

Reference yield:

anthranilic acid amide (28144-70-9,88-68-6) + 4-Methoxybenzyl alcohol (105-13-5) → 2-(4-methoxyphenyl)-3H-quinazolin-4-one (1152-07-4) + 2-<(4-methoxybenzyl)amino>benzamide (111232-48-5)

Guidance literature:

With bis[dichloro(pentamethylcyclopentadienyl)iridium(III)]; In 5,5-dimethyl-1,3-cyclohexadiene; for 24h; Inert atmosphere; Reflux;

DOI:10.1021/jo201054k

Reference yield: 90.0%

2-<(4-methoxybenzyl)amino>benzamide (111232-48-5) + cyclohexanone (108-94-1,11119-77-0,9003-41-2,9075-99-4) → 1-(4-methoxybenzyl)spiro-4'-one (111232-49-6)

Guidance literature:

for 58h; Heating;

DOI:10.3987/R-1987-01-0191

upstream raw materials:

p-Methoxybenzyl bromide

anthranilic acid amide

4-Methoxybenzyl alcohol

Downstream raw materials:

1-(4-methoxyphenyl)-1'-methylspiro-4'-one

1-(4-methoxybenzyl)spiro-4'-one

9-chloro-1,2,3,4-tetrahydroacridine

1,2,3,4,9,10-hexahydroacridin-9-one