2-(4-methoxyphenyl)-1H-quinazolin-4-one

Base Information

• Chemical Name: 2-(4-methoxyphenyl)-1H-quinazolin-4-one
• CAS No.: 1152-07-4
• Molecular Formula: C15H12N2O2
• Molecular Weight: 252.272
• Hs Code.: 2933990090
• Mol file: 1152-07-4.mol

Synonyms:2-(4-methoxyphenyl)-3H-quinazolin-4-one;2-[4-(methyloxy)phenyl]quinazolin-4(3H)-one;2-(4-methoxyphenyl)quinazolin-4-ol;2-(4-methoxyphenyl)quinazolin-4(3H)-one;2-(p-methoxyphenyl)quinazolin-4(3H)-one;2-(p-methoxyphenyl)-4(3H)quinazolinone;

Chemical Property of 2-(4-methoxyphenyl)-1H-quinazolin-4-one

Chemical Property:

• Melting Point: 200 °C
• Boiling Point: 431.3±47.0 °C(Predicted)
• PKA: 6.57±0.20(Predicted)
• PSA: 54.98000
• Density: 1.25±0.1 g/cm3(Predicted)
• LogP: 2.59870

Purity/Quality:

98%,99%, ^*data from raw suppliers

2-(4-Methoxyphenyl)quinazolin-4(3H)-one 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(4-methoxyphenyl)-1H-quinazolin-4-one

There total 126 articles about 2-(4-methoxyphenyl)-1H-quinazolin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4-methoxy-benzylamine (2393-23-9) + anthranilic acid amide (28144-70-9,88-68-6) → 2-(4-methoxyphenyl)-3H-quinazolin-4-one (1152-07-4)

Guidance literature:

With copper(l) iodide; 1,10-phenanthroline-5,6-dione; toluene-4-sulfonic acid; In chlorobenzene; at 100 ℃; for 24h; under 760.051 Torr;

DOI:10.1039/d0cy01764g

Reference yield: 96.0%

anthranilic acid amide (28144-70-9,88-68-6) + 4-Methoxybenzyl alcohol (105-13-5) → 2-(4-methoxyphenyl)-3H-quinazolin-4-one (1152-07-4)

Guidance literature:

With Iron(III) nitrate nonahydrate; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; oxygen; potassium hydroxide; In toluene; at 100 ℃; for 12h;

DOI:10.1039/c6ra12164k

Reference yield: 96.0%

anthranilic acid amide (28144-70-9,88-68-6) + ethyl 4-methoxybenzoylacetate (2881-83-6) → 2-(4-methoxyphenyl)-3H-quinazolin-4-one (1152-07-4)

Guidance literature:

With ethanolamine-phosphoric acid functionalized polyacrylonitrile fibers, hydrophobized with benzylamine (Bn-PAN_EAPF); In ethanol; at 80 ℃; for 15h; Green chemistry;

DOI:10.1039/c7gc02935g

upstream raw materials:

2-(4-Methoxybenzamido)benzamide

2,3-dihydro-2-(4-methoxyphenyl)-4(1H)-quinazolinone

N-(2-ethoxycarbonylphenyl)-4-methoxythiobenzamide

N-(2-cyclohexylcarbamoylphenyl)-4-methoxythiobenzamide

Downstream raw materials:

2-(4-hydroxyphenyl)-4(3H)-quinazolinone

2-(4-methoxylphenyl)-4-phenylquinazoline

4-(4-chlorophenyl)-2-(4-methoxyphenyl)quinazoline

2-(4-methoxyphenyl)-4-(p-tolyl)quinazoline