1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane

Base Information

• Chemical Name: 1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane
• CAS No.: 81347-68-4
• Molecular Formula: C₁₆H₁₄ClF₃O
• Molecular Weight: 314.735
• Mol file: 81347-68-4.mol

Synonyms:1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane

Chemical Property of 1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane

There total 8 articles about 1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

4-hydroxybenzotrifluoride (402-45-9) + 3-chloro-1-phenyl-propan-1-ol (18776-12-0,125712-82-5) → 1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane (81347-68-4)

Guidance literature:

4-hydroxybenzotrifluoride; With di-isopropyl azodicarboxylate; triphenylphosphine; In tetrahydrofuran; at 20 ℃; for 0.333333h;

3-chloro-1-phenyl-propan-1-ol; In tetrahydrofuran; at 20 ℃;

Reference yield: 38.0%

4-hydroxybenzotrifluoride (402-45-9) + cinnamyl chloride (2687-12-9) → 1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane (81347-68-4)

Guidance literature:

With 1-hydroxy-1,2-benzodioxol-3-(1H)-one; 1,1,2,2-tetramethyl-1,2-ethanediamino-N,N'-bis(3,5-di-tert-butylsalicylidene)-cobalt(II); tris(bipyridine)ruthenium(II) dichloride hexahydrate; 1,1,3,3-Tetramethyldisiloxane; In dichloromethane; at 20 ℃; Irradiation;

DOI:10.1021/acscatal.0c01209

Reference yield:

1-bromo-3-chloro-1-phenylpropane (21763-00-8) + 4-hydroxybenzotrifluoride (402-45-9) → 1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane (81347-68-4)

Guidance literature:

4-hydroxybenzotrifluoride; With sodium hydride; In N,N-dimethyl-formamide; at 20 ℃; for 0.5h;

1-bromo-3-chloro-1-phenylpropane; In N,N-dimethyl-formamide; at 20 ℃; for 60h;

DOI:10.1021/jm049856v

upstream raw materials:

1-bromo-3-chloro-1-phenylpropane

4-hydroxybenzotrifluoride

3-chloropropiophenone

3-chloro-1-phenyl-propan-1-ol

Downstream raw materials:

FLUOXETINE

N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)-1-propylamine

norfluoxetine

Refernces

• 1、 Andersen, Jacob,Stuhr-Hansen, Nicolai,Zachariassen, Linda Gronborg,Koldso, Heidi,Schiott, Birgit,Stromgaard, Kristian,Kristensen, Anders S.. "Molecular basis for selective serotonin reuptake inhibition by the antidepressant agent fluoxetine (Prozac)". supporting information. p. 703 - 714. Retrieved 2014/04/17.
• 2、 Silvestri, Romano,Artico, Marino,La Regina, Giuseppe,Di Pasquali, Alessandra,De Martino, Gabriella,D'Auria, Felicia Diodata,Nencioni, Lucia,Palamara, Anna Teresa. "Imidazole analogues of fluoxetine, a novel class of anti-Candida agents". . p. 3924 - 3926. Retrieved 2007/10/03.