Norfluoxetine

Base Information

• Chemical Name: Norfluoxetine
• CAS No.: 83891-03-6
• Deprecated CAS: 56161-73-0
• Molecular Formula: C16H16F3NO
• Molecular Weight: 331.765
• Hs Code.: 2922299090
• NSC Number: 675448
• UNII: K8D70XE2F4
• DSSTox Substance ID: DTXSID80866540
• Nikkaji Number: J274.757J
• Wikipedia: Seproxetine
• Wikidata: Q7452012
• Pharos Ligand ID: 9V2DLMQ31TZW
• ChEMBL ID: CHEMBL1494
• Mol file: 83891-03-6.mol

Synonyms:desmethylfluoxetine;norfluoxetin;norfluoxetine;norfluoxetine hydrochloride;norfluoxetine, (+-)-isomer

Chemical Property of Norfluoxetine

Chemical Property:

• Vapor Pressure: 5.21E-06mmHg at 25°C
• Melting Point: 105-108°C
• Refractive Index: 1.525
• Boiling Point: 381.1°C at 760 mmHg
• PKA: 9.05±0.13(Predicted)
• Flash Point: 184.3°C
• PSA: 35.25000
• Density: 1.204g/cm³
• LogP: 5.67660
• Storage Temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
• Solubility.: H2O: >4 mg/mL
• XLogP3: 3.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 5
• Rotatable Bond Count: 5
• Exact Mass: 295.11839862
• Heavy Atom Count: 21
• Complexity: 294

Purity/Quality:

98%min ^*data from raw suppliers

3-Phenyl-3-(4-trifluoromethyl-phenoxy)-propylamine 90% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(CCN)OC2=CC=C(C=C2)C(F)(F)F

Technology Process of Norfluoxetine

There total 3 articles about Norfluoxetine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

1-phthalamide-3-(4-trifluormethyl-phenoxy)-3-phenyl-propane → norfluoxetine (83891-03-6,56161-73-0)

Guidance literature:

With methanol; hydrazine; In dichloromethane; at 20 ℃; for 8h;

Reference yield:

1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane (81347-68-4) → norfluoxetine (83891-03-6,56161-73-0)

Guidance literature:

With sodium hydroxide; sodium borohydrid; In water; N,N-dimethyl-formamide; isopropyl alcohol;

Reference yield:

→ norfluoxetine (83891-03-6,56161-73-0)

Guidance literature:

upstream raw materials:

1-chloro-3-phenyl-3-(4-trifluoromethylphenoxy)propane

Downstream raw materials:

N,N-dimethyl-3-phenyl-3-(4-(trifluoromethyl)phenoxy)-1-propylamine

2-oxo-N-(3-phenyl-3-(4-(trifluoromethyl)phenoxy)propyl)propanamide

(R)-Norfluoxetine

(S)-norfluoxetine

Refernces

• 1、 -. "Aryloxyphenylpropylamines". . . Retrieved 2008/06/13.