3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine

Base Information

Chemical Name:3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine
CAS No.:634186-01-9
Molecular Formula:C₂₈H₂₄BrN₅O
Molecular Weight:526.435
Hs Code.:

Synonyms:3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine

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Chemical Property of 3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine

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Technology Process of 3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine

There total 4 articles about 3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 28.0%

: 2972-74-9
2-(3-bromobenzylidene)malononitrile

: 259260-15-6
1-(6-morpholinopyridin-3-yl)-3-phenylpropanone

: 634186-01-9
3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine

Guidance literature:: With ammonium acetate; In butan-1-ol; for 16h; Heating;
DOI:10.1021/jm030327l

Reference yield:

: 58757-38-3
6-Chloronicotinoyl chloride

: 634186-01-9
3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine

Guidance literature:: Multi-step reaction with 4 steps

1: Et₃N / CH₂Cl₂ / 2 h / 0 °C

2: 3.77 g / tetrahydrofuran / 3 h / 20 °C

3: 100 percent / ethanol / 18 h / Heating

4: 28 percent / NH₄OAc / butan-1-ol / 16 h / Heating

With ammonium acetate; triethylamine; In tetrahydrofuran; ethanol; dichloromethane; butan-1-ol;
DOI:10.1021/jm030327l

Reference yield:

: 149281-42-5
6-chloro-N-methoxy-N-methylpyridine-3-carboxamide

: 634186-01-9
3-cyano-4-(3-bromophenyl)-5-benzyl-6-(9-morpholinopyridin-3-yl)-2-pyridineamine

Guidance literature:: Multi-step reaction with 3 steps

1: 3.77 g / tetrahydrofuran / 3 h / 20 °C

2: 100 percent / ethanol / 18 h / Heating

3: 28 percent / NH₄OAc / butan-1-ol / 16 h / Heating

With ammonium acetate; In tetrahydrofuran; ethanol; butan-1-ol;
DOI:10.1021/jm030327l