2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

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Chemical Name:2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline
CAS No.:1555701-25-1
Molecular Formula:C₂₄H₂₆F₄N₄O
Molecular Weight:462.49
Hs Code.:

Synonyms:2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

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Chemical Property of 2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

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Technology Process of 2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

There total 10 articles about 2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1555701-23-9
5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1555701-25-1
2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In tetrahydrofuran; methanol; at 20 ℃; for 1h;

Reference yield:

: 1555700-42-9
4-bromo-5-fluoro-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1555701-25-1
2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

Guidance literature:: Multi-step reaction with 6 steps

1: bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 110 °C

2: water; hydrogenchloride / tetrahydrofuran / 2 h / 20 °C

3: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.25 h / Inert atmosphere; Microwave irradiation

4: acetic acid; hydrazine / 1.5 h / 90 °C

5: N,N-dimethyl-formamide / 1 h / 90 °C

6: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; palladium 10% on activated carbon; water; hydrogen; sodium hydride; acetic acid; hydrazine; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1397237-98-7
5-bromo-4-fluoro-2-methoxyaniline

: 1555701-25-1
2-(5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethylindolin-1-yl)aniline

Guidance literature:: Multi-step reaction with 9 steps

1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: dichloromethane; methanol / 3 h / 20 °C

2.2: 22 h / 0 - 50 °C

2.3: 0 °C

3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 16 h / Inert atmosphere; Reflux

4.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 110 °C

5.1: water; hydrogenchloride / tetrahydrofuran / 2 h / 20 °C

6.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.25 h / Inert atmosphere; Microwave irradiation

7.1: acetic acid; hydrazine / 1.5 h / 90 °C

8.1: N,N-dimethyl-formamide / 1 h / 90 °C

9.1: palladium 10% on activated carbon; hydrogen / methanol; tetrahydrofuran / 1 h / 20 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; palladium 10% on activated carbon; water; hydrogen; sodium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; hydrazine; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;