5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

Base Information

Chemical Name:5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline
CAS No.:1555701-23-9
Molecular Formula:C₂₄H₂₄F₄N₄O₃
Molecular Weight:492.473
Hs Code.:

Synonyms:5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

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Chemical Property of 5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

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Technology Process of 5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

There total 9 articles about 5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.2%

: 75-30-9
2-iodo-propane

: 1555701-21-7
5-fluoro-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)-4-(5-(trifluoromethyl)-1H-pyrazol-3-yl)indoline

: 1555701-69-3
5-fluoro-4-(1-isopropyl-3-(trifluoromethyl)-1H-pyrazol-5-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1555701-23-9
5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

Guidance literature:: In N,N-dimethyl-formamide; at 90 ℃; for 1h;

Reference yield:

: 1555700-42-9
4-bromo-5-fluoro-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

: 1555701-23-9
5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

Guidance literature:: Multi-step reaction with 5 steps

1: bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 110 °C

2: water; hydrogenchloride / tetrahydrofuran / 2 h / 20 °C

3: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.25 h / Inert atmosphere; Microwave irradiation

4: acetic acid; hydrazine / 1.5 h / 90 °C

5: N,N-dimethyl-formamide / 1 h / 90 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; water; sodium hydride; acetic acid; hydrazine; In tetrahydrofuran; 1,2-dimethoxyethane; N,N-dimethyl-formamide; toluene; mineral oil;

Reference yield:

: 1397237-98-7
5-bromo-4-fluoro-2-methoxyaniline

: 1555701-23-9
5-fluoro-4-(1-isopropyl-5-(trifluoromethyl)-1H-pyrazol-3-yl)-7-methoxy-3,3-dimethyl-1-(2-nitrophenyl)indoline

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium nitrite; hydrogenchloride / water / 1 h / 0 °C

1.2: 1 h / 0 °C

2.1: dichloromethane; methanol / 3 h / 20 °C

2.2: 22 h / 0 - 50 °C

2.3: 0 °C

3.1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 16 h / Inert atmosphere; Reflux

4.1: bis-triphenylphosphine-palladium(II) chloride / toluene / 16 h / 110 °C

5.1: water; hydrogenchloride / tetrahydrofuran / 2 h / 20 °C

6.1: sodium hydride / 1,2-dimethoxyethane; mineral oil / 0.25 h / Inert atmosphere; Microwave irradiation

7.1: acetic acid; hydrazine / 1.5 h / 90 °C

8.1: N,N-dimethyl-formamide / 1 h / 90 °C

With hydrogenchloride; bis-triphenylphosphine-palladium(II) chloride; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; water; sodium hydride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; acetic acid; hydrazine; sodium nitrite; In tetrahydrofuran; methanol; 1,2-dimethoxyethane; dichloromethane; water; N,N-dimethyl-formamide; toluene; mineral oil;