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1127-74-8

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1127-74-8 Usage

General Description

1,2,3,4-Tetrahydro-benzo[b]azepin-5-one is a organic compound, characterized as a heterocyclic compound which is any organic compound that contains a cyclic structure formed by atoms of at least two different elements. It exists as a seven-membered ring structure with a ketone functional group at the 5-carbon position. It is a member of the Tetrahydrobenzoazepines class of chemicals which are known to have therapeutic value for a range of health conditions including neurological disorders. However, specific properties such as its physical characteristics, reactivity, and toxicity are not largely studied or documented in the literature currently. Consequently, its applications and implications are not completely explored and caution in handling is advised.

Check Digit Verification of cas no

The CAS Registry Mumber 1127-74-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 1,1,2 and 7 respectively; the second part has 2 digits, 7 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1127-74:
(6*1)+(5*1)+(4*2)+(3*7)+(2*7)+(1*4)=58
58 % 10 = 8
So 1127-74-8 is a valid CAS Registry Number.
InChI:InChI=1/C10H11NO/c12-10-6-3-7-11-9-5-2-1-4-8(9)10/h1-2,4-5,11H,3,6-7H2

1127-74-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 16, 2017

Revision Date: Aug 16, 2017

1.Identification

1.1 GHS Product identifier

Product name 1,2,3,4-Tetrahydro-benzo[b]azepin-5-one

1.2 Other means of identification

Product number -
Other names 1,2,3,4-Tetrahydro-5H-1-benzazepin-5-one

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:1127-74-8 SDS

1127-74-8Relevant articles and documents

Practical Synthesis of N-{4-[(2-Methyl-4,5-dihydroimidazo[4,5-d][1] benzazepin-6(1H)-yl)carbonyl]phenyl}biphenyl-2-carboxamide Monohydrochloride: An Arginine Vasopressin Antagonist

Tsunoda, Takashi,Yamazaki, Atsuki,Iwamoto, Hidenori,Sakamoto, Shuichi

, p. 883 - 887 (2003)

A novel, reliable, and cost-effective synthetic route to N-{4-[(2-methyl-4,5-dihydroimidazo[4,5-d][1]benzazepin-6(1H)-yl)carbonyl] -phenyl}biphenyl-2-carboxamide monohydrochloride (1, YM087), a potent Arginine vasopressin antagonist, has been developed. Using moisture-controlled potassium carbonate, imidazole formation from α-bromoketone furnished imidazobenzazepine, avoiding potential oxazole-ring formation. Catalytic reduction of nitro imidazobenzazepine afforded the corresponding amine in high yields. Treatment of the imidazole-containing amine directly, with a carbonyl chloride, afforded the target amide circumventing protection of the imidazole.

Benzo [b] aza-chalcone heterocomplex as well as preparation method and application thereof

-

, (2021/05/12)

The invention discloses a benzo [b] aza-chalcone heterocomplex as well as a preparation method and application thereof, and relates to the technical field of medicinal chemistry, the benzo [b] aza-chalcone heterocomplex is prepared by retaining a natural chalcone parent structure (1, 3-diphenyl propenone) with certain anti-tumor activity by adopting a medicine combination principle and meanwhile introducing a benzo [b] aza structure with a special structure type and electron cloud distribution to obtain the novel benzo [b] aza-chalcone heterocomplex; and pharmacological studies show that the compound can significantly inhibit the activity of human gastric cancer cells HGC-27, the activity of the compound is obviously higher than that of positive control cis-platinum, and meanwhile, the compound has low toxicity to human normal gastric mucosa cells GES-1 and is obviously lower than that of the positive control cis-platinum.

Stereochemistry of N-Benzoyl-5-substituted-1-benzazepines Revisited: Synthesis of the Conformationally Biased Derivatives and Revision of the Reported Structure

Tabata, Hidetsugu,Yoneda, Tetsuya,Tasaka, Tomohiko,Ito, Shigekazu,Oshitari, Tetsuta,Takahashi, Hideyo,Natsugari, Hideaki

, p. 3136 - 3148 (2016/05/19)

The syn (aR?,5R?) and anti (aS?,5R?) diastereomers of N-benzoyl-C5-substituted-1-benzazepines originating in the chiralities at C5 and the Ar-N(C=O) axis were first stereoselectively synthesized by biasing the conformation with a substituent at C6 and C9, respectively. Detailed examination of the stereochemistry (i.e., conformation and configuration) of these N-benzoyl-1-benzazepines by X-ray crystallographic analysis, VT NMR, and DFT calculations revealed new physicochemical aspects of these heterocycles including revision of the stereochemistry previously reported.

COMPOUNDS AND METHODS FOR TREATING DYSLIPIDEMIA

-

Page/Page column 39, (2008/06/13)

Compounds of formula I wherein n, m, p, q, Y, R1 R2, R3, R4, R5, and R6 are as defined herein and their pharmaceutical compositions and methods of use are disclosed as useful for treating artherosclerosis and its sequelae.

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