1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole

Base Information

• Chemical Name: 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole
• CAS No.: 616209-43-9
• Molecular Formula: C₁₈H₁₅F₃N₂S
• Molecular Weight: 348.392
• Mol file: 616209-43-9.mol

Synonyms:1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole

Chemical Property of 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole

There total 5 articles about 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

Dimethyldisulphide (624-92-0) + 1-(4-bromophenyl)-5-(p-tolyl)-3- (trifluoromethyl)-1H-pyrazole → 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole (616209-43-9)

Guidance literature:

1-(4-bromophenyl)-5-(p-tolyl)-3- (trifluoromethyl)-1H-pyrazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

Dimethyldisulphide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 12h; Inert atmosphere;

DOI:10.1021/jacs.1c00529

Reference yield: 50.0%

→ 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole (616209-43-9)

Guidance literature:

Reference yield: 32.0%

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione (720-94-5) + [p-(methylthio)phenyl]hydrazine hydrochloride (58626-97-4,35588-53-5) → 1-(4-(methylthio)phenyl)-5-(p-tolyl)-3-(trifluoromethyl)-1H-pyrazole (616209-43-9)

Guidance literature:

With acetic acid; In ethanol; at 180 ℃; for 0.333333h; microwave irradiation;

DOI:10.1021/jm0705096

upstream raw materials:

4,4,4-trifluoro-1-(4-methylphenyl)butane-1,3-dione

[p-(methylthio)phenyl]hydrazine hydrochloride

para-methylacetophenone

4-methylsulfanylaniline

Downstream raw materials:

1-(4-Methanesulfinyl-phenyl)-5-p-tolyl-3-trifluoromethyl-1H-pyrazole

1-(4-(methylsulfonyl)phenyl)-5-(4-methylphenyl)-3-(trifluoromethyl)-1Hpyrazole