(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

Base Information

Chemical Name:(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate
CAS No.:1092557-63-5
Molecular Formula:C₁₆H₁₆O₆
Molecular Weight:304.299
Hs Code.:

Synonyms:(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

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Technology Process of (E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

There total 5 articles about (E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: methyl 2-(4-iodo-3-methoxy-5-oxofuran-2(5H)-ylidene)propanoate

: 5720-07-0
4-methoxyphenylboronic acid

: 1092557-63-5
(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In water; acetonitrile; at 85 ℃; for 6.5h; Inert atmosphere;
DOI:10.1021/jm801500h

Reference yield:

: 1092557-62-4
C₁₆H₁₈O₇

: 1092557-63-5
(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

: 1415681-29-6
(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

Guidance literature:: With dmap; triethylamine; trifluoroacetic anhydride; In dichloromethane; at 0 - 25 ℃; optical yield given as %de;
DOI:10.1002/cmdc.201000391

Reference yield:

: 58368-11-9
4-Methoxy-3-(4-methoxyphenyl)-furan-2(5H)-one

: 1092557-63-5
(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

: 1415681-29-6
(E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -78 °C

1.2: 0.5 h / -78 °C

2.1: dmap; triethylamine; trifluoroacetic anhydride / dichloromethane / 0 - 25 °C

With dmap; triethylamine; trifluoroacetic anhydride; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane;
DOI:10.1002/cmdc.201000391