58368-11-9

Upstream product

• 100074-36-0 (4-Methoxy-phenyl)-acetic acid ethoxycarbonylmethyl ester 
• 104-01-8 4-Methoxyphenylacetic acid 
• 33155-61-2 tert-butyl 2-(4-methoxyphenyl)acetate 
• 23786-14-3 4-methoxy-phenyl acetic acid methyl ester 
• 69556-70-3 4-methoxy-5H-furan-2-one 
• 71387-05-8 4-methoxy-3-bromo-furan-2(5H)-one 
• 5720-07-0 4-methoxyphenylboronic acid 
• 93831-11-9 4-Hydroxy-3-(4-methoxyphenyl)-furan-2(5H)-one 
• 77-78-1 dimethyl sulfate 

Downstream Products

• 100074-75-7 5-Bromo-4-methoxy-3-(4-methoxy-phenyl)-5H-furan-2-one 
• 1092557-62-4 C₁₆H₁₈O₇ 
• 1092557-63-5 (E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate 
• 1415681-29-6 (E)-Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate 
• 1092557-61-3 3-(4-methoxyphenyl)-6-methylfuro[3,2-b]furan-2,5-dione 
• 1415681-26-3 (2E,2′E)-N,N′-(Propane-1,3-diyl)bis(2-(3-hydroxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene) propanamide) 
• 1146510-10-2 Methyl 2-(3-methoxy-4-(4-methoxyphenyl)-5-oxofuran-2(5H)-ylidene)-propanoate 

Relevant academic research and scientific papers

Compound, as well as preparation method and application thereof

The application discloses a compound of which the structure is represented as the following formula, wherein R1 is selected from any one of F, Cl, Br, C1-C5 alkyl group, and a group having the structure as the formula (1), n = 0, 1, 2, 3, 4 or 5; the R2 is selected from any one of a group having the structure as the formula (1), a group having the structure as the formula (2), and a group having the structure as the formula (3). The compound has simple preparation method, can be used as a neuraminidase inhibitor, and has excellent antivirus activity.

A new series of Cs+, K+ and Na+ chelators: Synthesis, kinetics, thermodynamics and modeling

The synthesis of two molecules, B1 and B2, based on elements of norbadione A, the natural Cs+ chelator in mushrooms, associated, in the case of B2, with an 18-crown-6 ether is reported. Thermodynamic and kinetic analyses performed in water, ethanol and ethanol/water 9/1 v/v (M1) show in M1 and ethanol that B1 and B2 form stable complexes with Na+, K+ and Cs+. Affinity constants, measured spectrophotometrically in ethanol and M1, by the use of the Specfit program, are in the 105 and 106 range for B1 and B2, respectively. The second-order rate constants are in the 106-107 M-1 s-1 range and the first-order rate constants about unity. The ratios of the second-order/first-order rate constants confirm the thermodynamic results in EtOH. The kinetic processes become much too fast to allow runs in M1. Molecular simulations in EtOH imply the existence of two isomers for each of the Cs +/B1 and Cs+/B2 complexes. With B1, the more stable one is that in which the two enolates are parallel and mimic the alkali-metal inclusion cavity already envisaged for norbadione A. With B2, two similar structures are extracted, in both of which Cs+ is included in the crown ether and capped by the enolate. The affinity of B1 for Cs+ is comparable to that of norbadione A, whereas that of B2 is higher. These results are encouraging as they introduce a new series of alkali chelators which can lead to molecules capable of complexing 137Cs+ for radioactive decontamination.

Synthesis and Radioprotective Properties of Pulvinic Acid Derivatives

A high-throughput screening method has highlighted the marked antioxidant activity of some pulvinic acid derivatives (PADs) towards oxidation of thymidine, under γ and UV irradiation, and Fenton-like conditions. Here, we report the synthesis of a series of new hydrophilic PADs and the evaluation of their radioprotective efficacy in cell culture. Using a cell-based fluorescent assay, we show that some of these compounds have a pronounced ability to prevent cell death caused by radiation and to allow the subsequent resumption of proliferation. Thus, PADs may be considered as a novel class of radioprotective agents.

An efficient procedure for the synthesis of 3-aryl-4-methoxy-2(5H)-furanones by using the microwave-promoted Suzuki-Miyaura coupling reactions

The Suzuki-Miyaura coupling reactions of 3-bromo-2(5H)-furanones with a variety of arylboronic acids, promoted by microwave heating, efficiently generate 3-aryl-2(5H)-furanones. This remarkably rapid process serves as the foundation for a simple method to

Synthesis of (E)- and (Z)-Pulvinones

Two new routes to pulvinones have been developed, one of which involves a novel Wittig reaction.For the first time, members of the E-series, including the parent (E)-pulvinone, are reported and the structural elucidation of the geometric isomers is descri

Dioxolanones as Synthetic Intermediates. Part 2. Synthesis of Tetronic Acids and Pulvinones

The utility of 1,3-dioxolan-4-ones as intermediates in the synthesis of tetronic acids is examined.The reaction of dioxolanone (1) with lithium enolates of 2-substituted methyl or t-butyl acetates at -78 deg C in tetrahydrofuran afforded a general synthesis of 2-substituted tetronic acids (3) - (8).Treatment of (1) with the anions of 2-substituted acetonitriles led to formation of the corresponding 3-substituted-2-aminofuran-4(5H)-ones (13) and (14).A route to unsymmetrically substituted pulvinones by reaction of 5-arylidene-2,2-pentamethylene-1,3-dioxolan-4-ones with appropriately substituted phenylacetic ester anions has been devised.Thus, the preparation of the naturally occurring pigment 3',4',4-trihydroxypulvinone (18) was achieved via intermediate in which the phenolic groups were protected as benzyl ethers.The dioxolanone (26) has been used in the preparation of 2-acyl-4-benzylidenetetronic acids.