N¹-(p-Chlorobenzoyl)-N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine

Base Information

• Chemical Name: N¹-(p-Chlorobenzoyl)-N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine
• CAS No.: 130117-99-6
• Molecular Formula: C₂₂H₁₈ClN₃O₄
• Molecular Weight: 423.856
• Mol file: 130117-99-6.mol

Synonyms:N¹-(p-Chlorobenzoyl)-N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine

Chemical Property of N¹-(p-Chlorobenzoyl)-N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N¹-(p-Chlorobenzoyl)-N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine

There total 3 articles about N¹-(p-Chlorobenzoyl)-N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

4-chloro-N-(4-methoxyphenyl)benzamide (4018-82-0) + N1-Tosyl-N1-(p-nitrophenyl)-N2-(m-nitrophenyl)acetamidine (130117-85-0) → N1-(p-Chlorobenzoyl)-N1-(p-methoxyphenyl)-N2-(m-nitrophenyl)acetamidine (130117-99-6)

Guidance literature:

With potassium tert-butylate; In tetrahydrofuran; for 24h; Ambient temperature;

DOI:10.1248/cpb.38.1379

Reference yield:

m-Nitroacetophenonoxime tosylate (130117-96-3) → N1-(p-Chlorobenzoyl)-N1-(p-methoxyphenyl)-N2-(m-nitrophenyl)acetamidine (130117-99-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 39 percent / dimethylformamide / 2 h / 90 °C

2: 68 percent / tert-BuOK / tetrahydrofuran / 24 h / Ambient temperature

With potassium tert-butylate; In tetrahydrofuran; N,N-dimethyl-formamide;

DOI:10.1248/cpb.38.1379

Reference yield:

(E)-1-(3-nitrophenyl)ethan-1-one oxime (87974-55-8) → N1-(p-Chlorobenzoyl)-N1-(p-methoxyphenyl)-N2-(m-nitrophenyl)acetamidine (130117-99-6)

Guidance literature:

Multi-step reaction with 3 steps

1: 69 percent / Et₃N / benzene / 24 h / Ambient temperature

2: 39 percent / dimethylformamide / 2 h / 90 °C

3: 68 percent / tert-BuOK / tetrahydrofuran / 24 h / Ambient temperature

With potassium tert-butylate; triethylamine; In tetrahydrofuran; N,N-dimethyl-formamide; benzene;

DOI:10.1248/cpb.38.1379

upstream raw materials:

4-chloro-N-(4-methoxyphenyl)benzamide

N¹-Tosyl-N¹-(p-nitrophenyl)-N²-(m-nitrophenyl)acetamidine

m-Nitroacetophenonoxime tosylate

(E)-1-(3-nitrophenyl)ethan-1-one oxime

Downstream raw materials:

ethyl 4-chlorobenzoate

N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine