4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97%

Base Information

• Chemical Name: 4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97%
• CAS No.: 4018-82-0
• Molecular Formula: C14H12ClNO2
• Molecular Weight: 261.708
• Hs Code.: 2924299090
• Mol file: 4018-82-0.mol

Synonyms:4-chloro-benzoic acid p-anisidide;4-Chlor-benzoesaeure-p-anisidid;N-(p-Chlorobenzoyl)-p-anisidine;4-chloro-N-(4-methoxyphenyl)-benzamide;4-CHLORO-N-(4-METHOXY-PHENYL)-BENZAMIDE;benzamide,4-chloro-n-(4-methoxyphenyl);

Chemical Property of 4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97%

Chemical Property:

• Vapor Pressure: 0.000185mmHg at 25°C
• Melting Point: 208-209 °C
• Boiling Point: 328.8°Cat760mmHg
• PKA: 12.55±0.70(Predicted)
• Flash Point: 152.7°C
• PSA: 38.33000
• Density: 1.281g/cm³
• LogP: 3.67390
• Storage Temp.: Refrigerator
• Solubility.: DMSO (Slightly), Methanol (Slightly, Heated)

Purity/Quality:

97% ^*data from raw suppliers

N-(p-Chlorobenzoyl)-p-anisidine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 4-Chloro-N-(4-Methoxyphenyl)benzaMide is a COX-1 inhibitor analgesics that do not cause gastric damage. N-(p-Chlorobenzoyl)-p-anisidine is a COX-1 inhibitor analgesics that do not cause gastric damage.

Technology Process of 4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97%

There total 19 articles about 4-Chloro-N-(4-Methoxyphenyl)benzaMide, 97% which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxy-aniline (104-94-9) + 4-chloro-benzoyl chloride (122-01-0) → 4-chloro-N-(4-methoxyphenyl)benzamide (4018-82-0)

Guidance literature:

With samarium; In acetonitrile; at 20 ℃; for 4h;

DOI:10.1016/j.tetlet.2010.09.048

Reference yield: 88.0%

Methyl 4-chlorobenzoate (1126-46-1) + 4-methoxy-aniline (104-94-9) → 4-chloro-N-(4-methoxyphenyl)benzamide (4018-82-0)

Guidance literature:

With zinc; In N,N-dimethyl-formamide; for 0.0166667h; microwave irradiation;

DOI:10.1139/v05-134

Reference yield: 81.2%

4-methoxy-aniline (104-94-9) + para-chlorobenzoic acid (74-11-3) → 4-chloro-N-(4-methoxyphenyl)benzamide (4018-82-0)

Guidance literature:

With pyridine; trichlorophosphate; at 50 ℃; for 3.5h; Cooling with ice;

upstream raw materials:

4-methoxy-aniline

N¹-(p-Chlorobenzoyl)-N¹,N²-di(p-methoxyphenyl)acetamidine

S-phenyl 4-chlorobenzothioate

S-(p-chlorophenyl) p-chlorobenzenecarbothioate

Downstream raw materials:

N-(4-nitrophenyl)-4-methylbenzenesulfonamide

N¹-(p-chlorobenzoyl)-N¹-(p-methoxyphenyl)-N²-(p-chlorophenyl)acetamidine

ethyl 4-chlorobenzoate

N¹-(p-methoxyphenyl)-N²-(m-nitrophenyl)acetamidine