ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

Base Information

Chemical Name:ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate
CAS No.:340756-99-2
Molecular Formula:C₂₉H₄₂N₄O₇S
Molecular Weight:590.741
Hs Code.:

Synonyms:ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

Suppliers and Price of ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

There total 5 articles about ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 340756-75-4
N-[5-((1R)-2-amino-1-hydroxy-ethyl)-2-hydroxy-phenyl]-methanesulfonamide

: 340756-94-7
ethyl 1-[4-(4-oxo-1-piperidinyl)benzoyl]-L-leucinate

: 340756-99-2
ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

Guidance literature:: With sodium tris(acetoxy)borohydride; acetic acid; In N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1021/jm000544b

Reference yield:

: 2743-40-0
L-leucine ethyl ester hydrochloride

: 340756-99-2
ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

Guidance literature:: Multi-step reaction with 2 steps

1: 76 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; N-methylmorpholine / CH₂Cl₂

2: 78 percent / NaBH(OAc)3; AcOH / dimethylformamide / 20 °C

With 4-methyl-morpholine; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000544b

Reference yield:

: 79421-38-8
4-(1,4-dioxa-8-aza-spiro[4.5]dec-8-yl)-benzoic acid ethyl ester

: 340756-99-2
ethyl N-(4-{4-[((2R)-2-hydroxy-2-{4-hydroxy-3-[(methylsulfonyl)amino]phenyl}ethyl)amino]-1-piperidinyl}benzoyl)-L-leucinate

Guidance literature:: Multi-step reaction with 4 steps

1: 99 percent / 2 N aq. NaOH / methanol; tetrahydrofuran / 2 h / Heating

2: 88 percent / aq. HCl / 15 h / 20 °C

3: 76 percent / 1-[3-(dimethylamino)propyl]-3-ethylcarbodiimide*HCl; N-methylmorpholine / CH₂Cl₂

4: 78 percent / NaBH(OAc)3; AcOH / dimethylformamide / 20 °C

With 4-methyl-morpholine; hydrogenchloride; sodium hydroxide; sodium tris(acetoxy)borohydride; acetic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm000544b