5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

Base Information

Chemical Name:5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine
CAS No.:1421372-58-8
Molecular Formula:C₂₅H₂₆ClN₇O₃
Molecular Weight:507.98
Hs Code.:

Synonyms:5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

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Chemical Property of 5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

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Technology Process of 5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

There total 6 articles about 5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 109-01-3
1-methyl-piperazine

: 1421372-54-4
N-(4-fluoro-2-methoxy-5-nitrophenyl)-4-(1-methyl-1H-indol-3-yl)-5-chloropyrimidine-2-amine

: 1421372-58-8
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

Guidance literature:: In 2,2,2-trifluoroethanol; at 120 - 140 ℃; for 1.5h; Microwave irradiation;

Reference yield:

: 937366-57-9
3-(2,5-dichloropyrimidine-4-yl)-1H-indole

: 1421372-58-8
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 3 steps

1.1: sodium hydride / tetrahydrofuran / 0.42 h / 0 °C / Inert atmosphere

1.2: 2 h / 0 - 20 °C / Inert atmosphere

2.1: toluene-4-sulfonic acid / 18 h / 125 °C

3.1: 2,2,2-trifluoroethanol / 1.5 h / 120 - 140 °C / Microwave irradiation

With sodium hydride; toluene-4-sulfonic acid; In tetrahydrofuran; 2,2,2-trifluoroethanol;

Reference yield:

: 1075705-01-9
4-fluoro-2-methoxy-5-nitro-phenylamine

: 1421372-58-8
5-chloro-N-[2-methoxy-4-(4-methylpiperazin-1-yl)-5-nitrophenyl]-4-(1-methylindol-3-yl)pyrimidin-2-amine

Guidance literature:: Multi-step reaction with 2 steps

1: toluene-4-sulfonic acid / 18 h / 125 °C

2: 2,2,2-trifluoroethanol / 1.5 h / 120 - 140 °C / Microwave irradiation

With toluene-4-sulfonic acid; In 2,2,2-trifluoroethanol;