C₁₄H₉F₂N

Base Information

• Chemical Name: C₁₄H₉F₂N
• CAS No.: 1363411-84-0
• Molecular Formula: C₁₄H₉F₂N
• Molecular Weight: 229.229
• Mol file: 1363411-84-0.mol

Synonyms:C₁₄H₉F₂N

Chemical Property of C₁₄H₉F₂N

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

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Technology Process of C₁₄H₉F₂N

There total 2 articles about C₁₄H₉F₂N which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

2,4-difluoro-6-iodo-aniline (582319-15-1) + phenylacetylene (536-74-3) → C14H9F2N (1363411-84-0)

Guidance literature:

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; sodium acetate; triethylamine; at 70 ℃; for 3h; Inert atmosphere;

DOI:10.1016/j.jfluchem.2011.09.008

Reference yield:

2,4-difluorophenylamine (367-25-9,76563-56-9) → C14H9F2N (1363411-84-0)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; iodic acid / 1,4-dioxane; water / 3 h / Reflux

2: copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; sodium acetate; triethylamine / 3 h / 70 °C / Inert atmosphere

With copper(l) iodide; trans-bis(triphenylphosphine)palladium dichloride; iodine; sodium acetate; iodic acid; triethylamine; In 1,4-dioxane; water; 2: Sonogashira coupling;

DOI:10.1016/j.jfluchem.2011.09.008

Reference yield: 92.0%

carbon dioxide (124-38-9,18923-20-1) + C14H9F2N (1363411-84-0) → 6,8-difluoro-4-hydroxy-3-phenylquinolin-2(1H)-one

Guidance literature:

carbon dioxide; C₁₄H₉F₂N; With 1,8-diazabicyclo[5.4.0]undec-7-ene; In acetonitrile; at 20 ℃; for 0.25h; Schlenk technique;

With silver nitrate; In acetonitrile; at 60 ℃; for 25h; under 760.051 Torr; Schlenk technique;

DOI:10.1016/j.jfluchem.2020.109720

upstream raw materials:

2,4-difluoro-6-iodo-aniline

phenylacetylene

2,4-difluorophenylamine

Downstream raw materials:

2-phenyl-5,7-difluoro-1H-indole