1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Base Information

Chemical Name:1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine
CAS No.:222848-82-0
Molecular Formula:C₃₃H₃₃ClN₂O₉
Molecular Weight:637.086
Hs Code.:

Synonyms:1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

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Chemical Property of 1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

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Technology Process of 1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

There total 5 articles about 1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 541-88-8
Chloroacetic anhydride

: 222848-72-8
1-{4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

: 435282-14-7
1-{2'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

: 222848-82-0
1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

: 1-{2',3'-O-bis(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Guidance literature:: Chloroacetic anhydride; 1-{4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine; With pyridine; In dichloromethane; at 20 ℃; for 1h;

With triethylamine; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1002/1522-2675(200202)85:2<399::AID-HLCA399>3.0.CO;2-2

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 222848-82-0
1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 91 percent / BSA; trimethylsilyl triflate / acetonitrile / 3 h / 65 °C

2.1: 88 percent / NH₃ / methanol / 20 °C

3.1: 34 percent / 4 Angstroem molecular sieves / pyridine / 20 °C

4.1: pyridine / CH₂Cl₂ / 1 h / 20 °C

4.2: 43 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

With pyridine; benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; ammonia; In pyridine; methanol; dichloromethane; acetonitrile;
DOI:10.1002/1522-2675(200202)85:2<399::AID-HLCA399>3.0.CO;2-2

Reference yield:

: 166830-00-8
1-(2',3',5'-tri-O-benzoyl-β-D-xylopyranosyl)thymine

: 222848-82-0
1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Guidance literature:: Multi-step reaction with 3 steps

1.1: 88 percent / NH₃ / methanol / 20 °C

2.1: 34 percent / 4 Angstroem molecular sieves / pyridine / 20 °C

3.1: pyridine / CH₂Cl₂ / 1 h / 20 °C

3.2: 43 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

With pyridine; 4 A molecular sieve; ammonia; In pyridine; methanol; dichloromethane;
DOI:10.1002/1522-2675(200202)85:2<399::AID-HLCA399>3.0.CO;2-2