1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Base Information

Chemical Name:1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine
CAS No.:222848-84-2
Molecular Formula:C₃₃H₃₄N₂O₉
Molecular Weight:602.641
Hs Code.:

Synonyms:1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

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Chemical Property of 1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

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Technology Process of 1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

There total 6 articles about 1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 222848-82-0
1-{3'-O-(chloroacetyl)-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

: 222848-84-2
1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Guidance literature:: With hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; at 20 ℃; for 10h;
DOI:10.1002/1522-2675(200202)85:2<399::AID-HLCA399>3.0.CO;2-2

Reference yield:

: 65-71-4,28806-14-6,691841-57-3
thymin

: 222848-84-2
1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Guidance literature:: Multi-step reaction with 5 steps

1.1: 91 percent / BSA; trimethylsilyl triflate / acetonitrile / 3 h / 65 °C

2.1: 88 percent / NH₃ / methanol / 20 °C

3.1: 34 percent / 4 Angstroem molecular sieves / pyridine / 20 °C

4.1: pyridine / CH₂Cl₂ / 1 h / 20 °C

4.2: 43 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

5.1: 91 percent / H₂; K₂CO₃ / Pd/C / tetrahydrofuran / 10 h / 20 °C

With pyridine; benzenesulfonamide; trimethylsilyl trifluoromethanesulfonate; 4 A molecular sieve; ammonia; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane; acetonitrile;
DOI:10.1002/1522-2675(200202)85:2<399::AID-HLCA399>3.0.CO;2-2

Reference yield:

: 166830-00-8
1-(2',3',5'-tri-O-benzoyl-β-D-xylopyranosyl)thymine

: 222848-84-2
1-{3'-O-acetyl-4'-O-[(4'',4'''-dimethoxytriphenyl)methyl]-β-D-xylopyranosyl}thymine

Guidance literature:: Multi-step reaction with 4 steps

1.1: 88 percent / NH₃ / methanol / 20 °C

2.1: 34 percent / 4 Angstroem molecular sieves / pyridine / 20 °C

3.1: pyridine / CH₂Cl₂ / 1 h / 20 °C

3.2: 43 percent / Et₃N / CH₂Cl₂ / 16 h / 20 °C

4.1: 91 percent / H₂; K₂CO₃ / Pd/C / tetrahydrofuran / 10 h / 20 °C

With pyridine; 4 A molecular sieve; ammonia; hydrogen; potassium carbonate; palladium on activated charcoal; In tetrahydrofuran; pyridine; methanol; dichloromethane;
DOI:10.1002/1522-2675(200202)85:2<399::AID-HLCA399>3.0.CO;2-2