N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide

Base Information

Chemical Name:N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide
CAS No.:473253-39-3
Molecular Formula:C₃₀H₃₄N₂O₉
Molecular Weight:566.608
Hs Code.:

Synonyms:N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide

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Chemical Property of N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide

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Technology Process of N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide

There total 4 articles about N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 74903-79-0
N-hydroxy-4-methoxybenzenecarboximidoyl chloride

: N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)acrylic hydroxamate

: 473253-39-3
N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide

Guidance literature:: With 4-methyl-morpholine; In ethyl acetate; at 20 ℃; for 3h;
DOI:10.1021/jm020183v

Reference yield:

: 70286-37-2
4-methoxy-benzaldehyde-(O-methyl-seqtrans-oxime )

: 473253-39-3
N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide

Guidance literature:: Multi-step reaction with 2 steps

1: 11.1 g / N-chlorosuccinimide; HCl / dimethylformamide / 1 h / 20 °C

2: 65 percent / N-methylmorpholine / ethyl acetate / 3 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; N-chloro-succinimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020183v

Reference yield:

: 123-11-5
4-methoxy-benzaldehyde

: 473253-39-3
N-(2,4,6-trimethoxybenzyl)-O-(2,4-dimethoxybenzyl)-3-(4-methoxyphenyl)-4,5-dihydro-isoxazole-5-carboxylic acid hydroxyamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride; aq. triethylamine / tetrahydrofuran / 4 h

2: 11.1 g / N-chlorosuccinimide; HCl / dimethylformamide / 1 h / 20 °C

3: 65 percent / N-methylmorpholine / ethyl acetate / 3 h / 20 °C

With 4-methyl-morpholine; hydrogenchloride; N-chloro-succinimide; hydroxylamine hydrochloride; triethylamine; In tetrahydrofuran; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1021/jm020183v