N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

Base Information

Chemical Name:N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide
CAS No.:1360624-58-3
Molecular Formula:C₁₆H₁₄ClF₂N₃O₄
Molecular Weight:385.755
Hs Code.:

Synonyms:N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

Chemical Property:

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Technology Process of N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

There total 1 articles about N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

: 371-62-0
2-fluoroethanol

: 1360624-59-4
N-(4-fluoro-3-chloro-phenyl)-2-fluoro-4-methylamino-5-nitro-benzoic acid amide

: 1360624-58-3
N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

Guidance literature:: With potassium hexamethylsilazane; In tetrahydrofuran; at 60 ℃; Cooling with ice;

Reference yield:

: 1360624-58-3
N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

: C₁₆H₁₆ClF₂N₃O₂

Guidance literature:: With hydrogen; palladium on activated charcoal; In tetrahydrofuran; for 8h; under 2250.23 Torr;

Reference yield:

: 1360624-58-3
N-(3-chloro-4-fluorophenyl)-2-(2-fluoroethoxy)-4-methylamino-5-nitro-benzamide

: 1360622-23-6
N-(3-chloro-4-fluoro-phenyl)-2-{2,6-dichloro-3-[(2,2-dimethyl-propionylamino)-methyl]-phenylamino}-6-(2-fluoroethoxy)-1-methyl-1H-benzimidazole-5-carboxylic acid amide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogen / palladium on activated charcoal / tetrahydrofuran / 8 h / 2250.23 Torr

2: 2 h / 20 °C

3: diisopropyl-carbodiimide / acetonitrile / 20 - 60 °C

With hydrogen; diisopropyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; acetonitrile;