(S)-2-tert-butylphenyl methyl sulfoxide

Base Information

• Chemical Name: (S)-2-tert-butylphenyl methyl sulfoxide
• CAS No.: 1308834-34-5
• Molecular Formula: C₁₁H₁₆OS
• Molecular Weight: 196.313
• Mol file: 1308834-34-5.mol

Synonyms:(S)-2-tert-butylphenyl methyl sulfoxide

Chemical Property of (S)-2-tert-butylphenyl methyl sulfoxide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-2-tert-butylphenyl methyl sulfoxide

There total 4 articles about (S)-2-tert-butylphenyl methyl sulfoxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

1-tert-butyl-2-(methylthio)benzene (33775-93-8) → (S)-2-tert-butylphenyl methyl sulfoxide (1308834-34-5) + (R)-2-tert-butylphenyl methyl sulfoxide (1308833-94-4)

Guidance literature:

With (+)-[(8,8-dichlorocamphoryl)sulfonyl]oxaziridine; In tetrachloromethane; at 20 ℃; for 48h; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ol2010962

Reference yield:

2-[(2-tert-butylphenyl)sulfinyl]ethyl phenyl sulfone (1308833-74-0) + methyl iodide (74-88-4) → (S)-2-tert-butylphenyl methyl sulfoxide (1308834-34-5) + (R)-2-tert-butylphenyl methyl sulfoxide (1308833-94-4)

Guidance literature:

With (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide; In dichloromethane; water; toluene; at 0 ℃; optical yield given as %ee; enantioselective reaction; Inert atmosphere;

DOI:10.1021/ol2010962

Reference yield:

2-tert-butylthiophenol (19728-41-7) → (S)-2-tert-butylphenyl methyl sulfoxide (1308834-34-5) + (R)-2-tert-butylphenyl methyl sulfoxide (1308833-94-4)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium carbonate / dichloromethane / 20 h / 20 °C / Inert atmosphere

2: dihydrogen peroxide / 2,2,2-trifluoroethanol; water / 0 - 20 °C

3: (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; sodium hydroxide / dichloromethane; water; toluene / 0 °C / Inert atmosphere

With (1S,2S,4S,5R)-1-(anthracen-9-ylmethyl)-2-((R)-hydroxy(quinolin-4-yl)methyl)-5-vinyl-1-azoniabicyclo[2.2.2]octane chloride; dihydrogen peroxide; potassium carbonate; sodium hydroxide; In dichloromethane; 2,2,2-trifluoroethanol; water; toluene;

DOI:10.1021/ol2010962

upstream raw materials:

2-[(2-tert-butylphenyl)sulfanyl]ethyl phenyl sulfone

2-[(2-tert-butylphenyl)sulfinyl]ethyl phenyl sulfone

methyl iodide

2-tert-butylthiophenol