4-benzoic acid

Base Information

• Chemical Name: 4-benzoic acid
• CAS No.: 147290-45-7
• Molecular Formula: C₁₆H₁₄N₂O₄
• Molecular Weight: 298.298
• Mol file: 147290-45-7.mol

Synonyms:4-benzoic acid

Chemical Property of 4-benzoic acid

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of 4-benzoic acid

There total 1 articles about 4-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-(aminoiminomethyl)benzoic acid (15535-95-2) + phenyl chloroformate (1885-14-9) → 4-benzoic acid (147290-45-7)

Guidance literature:

In methanol; sodium hydroxide;

Reference yield: 4.0%

4-benzoic acid (147290-45-7) + tert-butyl 7-amino-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-2-propanoate (147290-98-0) → t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate (147290-99-1)

Guidance literature:

With (benzotriazo-1-yloxy)tris(dimethylamino)phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jm980166z

Reference yield:

4-benzoic acid (147290-45-7) → 4-benzoyl chloride (147291-72-3)

Guidance literature:

With thionyl chloride; In dichloromethane; for 0.166667h; Heating;

DOI:10.1021/jm980166z

upstream raw materials:

4-(aminoiminomethyl)benzoic acid

phenyl chloroformate

Downstream raw materials:

{8-[4-(benzyloxycarbonylamino-imino-methyl)-benzoylamino]-3-oxo-1,3,4,5-tetrahydro-benzo[e][1,3]diazepin-2-yl}-acetic acid methyl ester

t-butyl 7-[[[4-(N-benzyloxycarbonylaminoiminomethyl)phenyl]carbonyl]amino]-3-oxo-1,2,3,5-tetrahydro-4H-1,4-benzodiazepine-4-propanoate

4-benzoyl chloride

C₃₂H₃₀ClN₇O₆