4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Base Information

Chemical Name:4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide
CAS No.:1450922-57-2
Molecular Formula:C₁₉H₁₂F₄N₄O₃S₂
Molecular Weight:484.455
Hs Code.:

Synonyms:4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Chemical Property of 4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

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Technology Process of 4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

There total 6 articles about 4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.0%

: 384858-14-4
N-[(4-methoxyphenyl)methyl]thiazole 2-amine

: 1450923-96-2
4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride

: 1450922-57-2
4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: N-[(4-methoxyphenyl)methyl]thiazole 2-amine; With lithium hexamethyldisilazane; In tetrahydrofuran; at 0 ℃; for 0.25h;

4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride; In tetrahydrofuran; at 0 - 20 ℃; for 1.5h;

With trifluoroacetic acid; at 0 - 20 ℃; for 1.33333h;
DOI:10.1016/j.bmcl.2017.05.070

Reference yield:

: 1450923-98-4
C₂₇H₂₀F₄N₄O₄S₂

: 1450922-57-2
4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 0 ℃; for 0.333333h;

Reference yield:

: 4088-84-0
2-fluoro-5-trifluoromethyl-benzonitrile

: 1450922-57-2
4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / mineral oil; tetrahydrofuran / 1.75 h / 0 - 20 °C / Cooling with ice

1.2: 60 °C

2.1: dichloromethane / 0.33 h

3.1: lithium hexamethyldisilazane / tetrahydrofuran / 0.25 h / Cooling with ice

4.1: trifluoroacetic acid / dichloromethane / 0.33 h / 0 °C

With sodium hydride; trifluoroacetic acid; lithium hexamethyldisilazane; In tetrahydrofuran; dichloromethane; mineral oil;