2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile

Base Information

• Chemical Name: 2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile
• CAS No.: 1450923-94-0
• Molecular Formula: C₁₆H₁₀F₄N₂O
• Molecular Weight: 322.262

Synonyms:2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile

Chemical Property of 2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile

Chemical Property:

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Technology Process of 2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile

There total 1 articles about 2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 63.0%

6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine (105655-00-3) + 2-fluoro-5-trifluoromethyl-benzonitrile (4088-84-0) → 2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile (1450923-94-0)

Guidance literature:

6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 - 20 ℃; for 1.75h; Inert atmosphere;

2-fluoro-5-trifluoromethyl-benzonitrile; at 0 ℃;

DOI:10.1016/j.bmcl.2017.05.070

Reference yield: 74.5%

2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile (1450923-94-0) → 4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride (1450923-96-2)

Guidance literature:

With chlorosulfonic acid; In dichloromethane; for 0.5h; Cooling with ice;

DOI:10.1016/j.bmcl.2017.05.070

Reference yield: 74.5%

chlorosulfonic acid (7790-94-5) + 2-(6-fluoro-2H-benzo[b][1,4]oxazin-4(3H)-yl)-5-(trifluoromethyl)benzonitrile (1450923-94-0) → 4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride (1450923-96-2)

Guidance literature:

In dichloromethane; for 0.333333h;

upstream raw materials:

6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine

2-fluoro-5-trifluoromethyl-benzonitrile

Downstream raw materials:

4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonyl chloride

4-(2-cyano-4-(trifluoromethyl)phenyl)-6-fluoro-N-(thiazol-2-yl)-3,4-dihydro-2H-benzo[b][1,4]oxazine-7-sulfonamide

C₂₇H₂₀F₄N₄O₄S₂

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