N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

Base Information

Chemical Name:N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide
CAS No.:1354443-77-8
Molecular Formula:C₄₂H₆₈N₁₀O₁₁
Molecular Weight:889.062
Hs Code.:

N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

Synonyms:N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

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Chemical Property of N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

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Technology Process of N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

There total 4 articles about N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: N-(6-aminohexyl)-2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamide

: 108787-91-3
Boc-Arg(Boc)2OH

: 1354443-77-8
N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

Guidance literature:: With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide;

Reference yield:

: 738-70-5
5-(3,4,5-trimethoxybenzyl)pyrimidine-2,4-diamine

: 1354443-77-8
N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: water; hydrogen bromide / 0.33 h / Reflux

2.1: sodium hydride / N,N-dimethyl-formamide; mineral oil

2.2: 0.5 h

3.1: lithium hydroxide; water / methanol / 4 h

4.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide

4.2: 24 h

4.3: 1 h

5.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; hydrogen bromide; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 21253-58-7
2,4-diamino-5-(3,5-dimethoxy-4-hydroxybenzyl)pyrimidine

: 1354443-77-8
N-(6-(2-(4-((2,4-diaminopyrimidin-5-yl)methyl)-2,6-dimethoxyphenoxy)acetamido)hexyl)-5-(2,3-di-t-butoxycarbonylguanidino)-2-(t-butoxycarbonylamino)pentanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil

1.2: 0.5 h

2.1: lithium hydroxide; water / methanol / 4 h

3.1: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / N,N-dimethyl-formamide

3.2: 24 h

3.3: 1 h

4.1: triethylamine; benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate / N,N-dimethyl-formamide

With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; water; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; lithium hydroxide; In methanol; N,N-dimethyl-formamide; mineral oil;