methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

Base Information

• Chemical Name: methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate
• CAS No.: 1364597-43-2
• Molecular Formula: C₁₆H₁₄ClN₃O₃
• Molecular Weight: 331.758

Synonyms:methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

Chemical Property of methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

There total 2 articles about methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

dimethyl 2-acetylsuccinate (10420-33-4) + 5-(3-chlorophenyl)-1H-pyrazole-3-amine (208519-09-9) → methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (1364597-43-2)

Guidance literature:

toluene-4-sulfonic acid; In o-xylene; for 2h; Reflux;

Reference yield: 99.0%

5-(3-chlorophenyl)-1H-pyrazol-3-amine (208519-09-9) + dimethyl 2-acetylsuccinate (10420-33-4) → methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (1364597-43-2)

Guidance literature:

With toluene-4-sulfonic acid; In o-xylene; for 2h; Dean-Stark; Reflux;

DOI:10.1021/acs.jmedchem.9b01681

Reference yield: 94.0%

methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (1364597-43-2) → methyl 2-(7-chloro-2-(3-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate (1364597-47-6)

Guidance literature:

With trichlorophosphate; for 2.5h; Reflux;

upstream raw materials:

dimethyl 2-acetylsuccinate

5-(3-chlorophenyl)-1H-pyrazole-3-amine

5-(3-chlorophenyl)-1H-pyrazol-3-amine

Downstream raw materials:

methyl 2-(7-chloro-2-(3-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

methyl 2-(7-chloro-2-(3-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

methyl 2-(7-chloro-2-(3-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-oxoacetate

(S)-methyl 2-(7-chloro-2-(3-chlorophenyl)-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)-2-hydroxyacetate

Post a RFQ

Cas No.:

Product Name:

Quantity:

Please select Metric Ton KG G Pound L ML

Email:

Company name:

Valid Period:

Detailed Requirements:

• Sample
• MOQ
• GMP
• FDA
• Price
  FOB CIF CFR EXW
• Urgent purchase

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

Remove

Submit

1

What can I do for you?
Get Best Price

Get Best Price for 1364597-43-2 methyl 2-(2-(3-chlorophenyl)-7-hydroxy-5-methylpyrazolo[1,5-a]pyrimidin-6-yl)acetate

Send

Send

Metric Ton KG G Pound L ML

Send

Send