1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

Base Information

Chemical Name:1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea
CAS No.:1555701-04-6
Molecular Formula:C₃₁H₂₇F₄N₃O₃
Molecular Weight:565.567
Hs Code.:

Synonyms:1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

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Chemical Property of 1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

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Technology Process of 1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

There total 8 articles about 1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1617505-01-7
2-[4-(4-fluorophenyl)-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl]aniline

: 35037-73-1
1-isocyanato-4-trifluoromethoxy-benzene

: 1555701-04-6
1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

Guidance literature:: In dichloromethane; Inert atmosphere;
DOI:10.1021/jm5006226

Reference yield:

: 1555701-59-1
3-[2-(4-bromo-7-methoxy-3,3-dimethyl-2,3-dihydro-1H-indol-1-yl)phenyl]-1-[4-(trifluoromethoxy)phenyl]urea

: 1765-93-1
4-fluoroboronic acid

: 1555701-04-6
1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; In 1,2-dimethoxyethane; water; at 100 ℃; for 48h; Sealed tube; Inert atmosphere;

Reference yield:

: 1531844-07-1
4-bromo-7-methoxy-3,3-dimethylindoline

: 1555701-04-6
1-(2-(4-(4-fluorophenyl)-7-methoxy-3,3-dimethylindolin-1-yl)phenyl)-3-(4-(trifluoromethoxy)phenyl)urea

Guidance literature:: Multi-step reaction with 4 steps

1: 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate / toluene / 16 h / 110 °C / Inert atmosphere; Sealed tube

2: zinc; ammonium chloride / 1 h / 20 °C / Inert atmosphere

3: dichloromethane / 16 h / 20 °C / Inert atmosphere

4: tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate / Dimethyl ether / 100 °C / Inert atmosphere; Sealed tube

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; ammonium chloride; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; zinc; In Dimethyl ether; dichloromethane; toluene; 4: |Suzuki Coupling;
DOI:10.1021/jm5006226