2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

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Chemical Name:2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester
CAS No.:865436-11-9
Molecular Formula:C₃₈H₅₇N₅O₁₀S
Molecular Weight:775.964
Hs Code.:

2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

Synonyms:2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

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Chemical Property of 2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

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Technology Process of 2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

There total 1 articles about 2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 865436-10-8
2S,3R,5S-4-(2-{[2-tert-butoxycarbonyl-2-(2,4,6-trimethylbenzenesulfonyl-tert-butoxycarbonylamino)-2-(tert-butoxycarbonyl)ethyl]amino}-2-oxoethoxy)-2-[(tert-butoxycarbonylpyridin-2-ylamino)methyl]pyrrolidine-1-carboxylic acid benzyl ester

: 865436-11-9
2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

Guidance literature:: With hydrogen; palladium 10% on activated carbon; In isopropyl alcohol; for 12h;

Reference yield: 61.0%

: 865436-11-9
2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester

: 76-05-1
trifluoroacetic acid

: 103-80-0
phenylacetyl chloride

: 865436-03-9
2S,4R,20S-3-(2-[1-phenylacetyl-5-(pyridin-2-ylaminomethyl)-pyrrolidin-3-yloxy]-acetylamino)-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid TFA-salt

Guidance literature:: 2S,4R,20S-3-[tert-butoxycarbonyl-(2-(5-[(tert-butoxycarbonyl-pyridin-2-yl-amino)-methyl]-pyrrolidin-3-yloxy)-acetyl)-amino]-2-(2,4,6-trimethyl-benzenesulfonylamino)-propionic acid tert-butyl ester; phenylacetyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 - 20 ℃; for 2h;

trifluoroacetic acid; at 20 ℃; for 4h;