(R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid

Base Information

Chemical Name:(R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid
CAS No.:956125-95-4
Molecular Formula:C₂₃H₂₄Cl₂N₂O₃
Molecular Weight:447.361
Hs Code.:

Synonyms:(R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid

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Chemical Property of (R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid

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Technology Process of (R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid

There total 10 articles about (R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 956125-94-3
(R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid methyl ester

: 956125-95-4
(R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid

Guidance literature:: With sodium hydroxide; water; In tetrahydrofuran; at 60 ℃; for 12h;

Reference yield:

: 956125-89-6
(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 956125-95-4
(R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C

1.2: 12 h / 20 °C

2.1: boron tribromide / 1,1-dichloroethane; dichloromethane / 13 h / -20 - 20 °C

3.1: pyridine / dichloromethane / 1 h / 0 °C

4.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 60 - 80 °C

5.1: sodium hydroxide; water / tetrahydrofuran / 12 h / 60 °C

With pyridine; sodium hydroxide; water; boron tribromide; sodium carbonate; acetic acid; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane; water;

Reference yield:

: 60964-09-2
2,6-dichloro-4-hydroxybenzaldehyde

: 956125-95-4
(R)-3',5'-dichloro-4'-(2-oxo-1-piperidin-1-yl-pyrrolidin-3-ylmethyl)-biphenyl-4-carboxylic acid

Guidance literature:: Multi-step reaction with 10 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium tetrahydroborate / ethanol / 2 h / 7 °C

3.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -75 - -25 °C

4.2: 4 h / -60 - 0 °C

5.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 4 h / 20 °C

6.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C

6.2: 12 h / 20 °C

7.1: boron tribromide / 1,1-dichloroethane; dichloromethane / 13 h / -20 - 20 °C

8.1: pyridine / dichloromethane / 1 h / 0 °C

9.1: sodium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / tetrahydrofuran; water / 3 h / 60 - 80 °C

10.1: sodium hydroxide; water / tetrahydrofuran / 12 h / 60 °C

With pyridine; sodium hydroxide; sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; water; boron tribromide; phosphorus tribromide; sodium carbonate; potassium carbonate; acetic acid; lithium diisopropyl amide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,1-dichloroethane; ethanol; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;