(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one

Base Information

Chemical Name:(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one
CAS No.:956125-92-1
Molecular Formula:C₁₆H₂₀Cl₂N₂O₂
Molecular Weight:343.253
Hs Code.:

Synonyms:(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one

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Chemical Property of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one

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Technology Process of (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one

There total 7 articles about (R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 956125-90-9
(R)-3-(2,6-dichloro-4-methoxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one hydrochloride

: 956125-92-1
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one

Guidance literature:: (R)-3-(2,6-dichloro-4-methoxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one hydrochloride; With boron tribromide; In 1,1-dichloroethane; dichloromethane; at -20 - 20 ℃; for 13h;

With water; sodium hydrogencarbonate; In 1,1-dichloroethane; dichloromethane;

Reference yield:

: 956125-89-6
(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

: 956125-92-1
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C

1.2: 12 h / 20 °C

2.1: boron tribromide / 1,1-dichloroethane; dichloromethane / 13 h / -20 - 20 °C

With boron tribromide; acetic acid; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane;

Reference yield:

: 86111-47-9
(2,6-dichloro-4-methoxy-phenyl)-methanol

: 956125-92-1
(R)-3-(2,6-dichloro-4-hydroxy-benzyl)-1-piperidin-1-yl-pyrrolidin-2-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C

2.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -75 - -25 °C

2.2: 4 h / -60 - 0 °C

3.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 4 h / 20 °C

4.1: acetic acid / tetrahydrofuran / 0.33 h / 20 °C

4.2: 12 h / 20 °C

5.1: boron tribromide / 1,1-dichloroethane; dichloromethane / 13 h / -20 - 20 °C

With sodium periodate; osmium(VIII) oxide; water; boron tribromide; phosphorus tribromide; acetic acid; lithium diisopropyl amide; In tetrahydrofuran; 1,1-dichloroethane; dichloromethane; tert-butyl alcohol;