(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

Base Information

Chemical Name:(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde
CAS No.:956125-89-6
Molecular Formula:C₂₂H₂₁Cl₂NO₅
Molecular Weight:450.318
Hs Code.:

Synonyms:(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

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Chemical Property of (R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

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Technology Process of (R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

There total 6 articles about (R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 956125-88-5
(R)-4-benzyl-3-[(S)-2-(4-methoxy-2,6-dichloro-benzyl)-pent-4-enoyl]-oxazolidin-2-one

: 956125-89-6
(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

Guidance literature:: With sodium periodate; osmium(VIII) oxide; water; In tetrahydrofuran; tert-butyl alcohol; at 20 ℃; for 4h; Product distribution / selectivity;

Reference yield:

: 60964-09-2
2,6-dichloro-4-hydroxybenzaldehyde

: 956125-89-6
(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 3 h / 20 °C

2.1: sodium tetrahydroborate / ethanol / 2 h / 7 °C

3.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C

4.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -75 - -25 °C

4.2: 4 h / -60 - 0 °C

5.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 4 h / 20 °C

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; water; phosphorus tribromide; potassium carbonate; lithium diisopropyl amide; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 82772-93-8
2,6-dichloro-4-methoxy-benzaldehyde

: 956125-89-6
(R)-4-((R)-benzyl-2-oxo-oxazolidin-3-yl)-3-(4-methoxy-2,6-dichloro-benzyl)-4-oxo-butyraldehyde

Guidance literature:: Multi-step reaction with 4 steps

1.1: sodium tetrahydroborate / ethanol / 2 h / 7 °C

2.1: phosphorus tribromide / tetrahydrofuran / 0.5 h / 0 °C

3.1: lithium diisopropyl amide / tetrahydrofuran / 0.5 h / -75 - -25 °C

3.2: 4 h / -60 - 0 °C

4.1: sodium periodate; osmium(VIII) oxide; water / tetrahydrofuran; tert-butyl alcohol / 4 h / 20 °C

With sodium tetrahydroborate; sodium periodate; osmium(VIII) oxide; water; phosphorus tribromide; lithium diisopropyl amide; In tetrahydrofuran; ethanol; tert-butyl alcohol;