9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine

Base Information

Chemical Name:9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine
CAS No.:440099-59-2
Molecular Formula:C₂₇H₃₉N₅O₄SSi
Molecular Weight:557.789
Hs Code.:

Synonyms:9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine

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Chemical Property of 9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine

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Technology Process of 9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine

There total 4 articles about 9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 930-69-8
sodium thiophenolate

: 440099-58-1
9-[2,3-anhydro-5-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl]-N6-pivaloyladenine

: 440099-59-2
9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine

Guidance literature:: In methanol; for 2.5h; Heating;
DOI:10.1016/S0040-4020(02)00153-9

Reference yield:

: 2627-64-7
9-(2,3-anhydro-β-D-ribofuranosyl)adenine

: 440099-59-2
9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine

Guidance literature:: Multi-step reaction with 3 steps

1: 88 percent / imidazole / dimethylformamide / 0.42 h / 0 °C

2: 97 percent / i-Pr₂NEt / CH₂Cl₂ / 1.5 h / 0 °C

3: 90 percent / methanol / 2.5 h / Heating

With 1H-imidazole; N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00153-9

Reference yield:

: 128803-97-4
9-<2,3-anhydro-5-O-(tert-butyldimethylsilyl)-β-D-ribofuranosyl>adenine

: 440099-59-2
9-[5-O-(tert-butyldimethylsilyl)-3-deoxy-3-C-phenylthio-β-D-xylofuranosyl]-N6-pivaloyladenine

Guidance literature:: Multi-step reaction with 2 steps

1: 97 percent / i-Pr₂NEt / CH₂Cl₂ / 1.5 h / 0 °C

2: 90 percent / methanol / 2.5 h / Heating

With N-ethyl-N,N-diisopropylamine; In methanol; dichloromethane;
DOI:10.1016/S0040-4020(02)00153-9