(4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

Base Information

Chemical Name:(4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate
CAS No.:1600565-45-4
Molecular Formula:C₂HF₃O₂*C₂₈H₂₁ClF₃N₃O₂
Molecular Weight:637.966
Hs Code.:

Synonyms:(4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

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Chemical Property of (4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

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Technology Process of (4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

There total 11 articles about (4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1600565-43-2
(4-chloro-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(4-chlorophenyl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

: 124-41-4
sodium methylate

: 1600565-45-4
(4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

Guidance literature:: In ethanol; at 82 ℃; for 24h; Sealed tube;

Reference yield:

: 122-01-0
4-chloro-benzoyl chloride

: 1600565-45-4
(4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

Guidance literature:: Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 72 h / 20 °C

2.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.33 h / Inert atmosphere; Cooling with ice

2.2: 20 °C / Inert atmosphere

3.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

3.2: 20 °C

4.1: ethanol / 24 h / 82 °C / Sealed tube

With pyridine; n-butyllithium; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; ethanol; hexane; dichloromethane;

Reference yield:

: 122334-37-6
4-chloro-N-methoxy-N-methylbenzamide

: 1600565-45-4
(4-chlorophenyl)(4-methoxy-3-phenyl-2-(trifluoromethyl)quinolin-6-yl)(1-methyl-1H-imidazol-5-yl)methanol trifluoroacetate

Guidance literature:: Multi-step reaction with 3 steps

1.1: ethylmagnesium bromide / tetrahydrofuran; diethyl ether / 0.33 h / Inert atmosphere; Cooling with ice

1.2: 20 °C / Inert atmosphere

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.17 h / -78 °C

2.2: 20 °C

3.1: ethanol / 24 h / 82 °C / Sealed tube

With n-butyllithium; ethylmagnesium bromide; In tetrahydrofuran; diethyl ether; ethanol; hexane;