(+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Base Information

Chemical Name:(+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile
CAS No.:892550-41-3
Molecular Formula:C₂₈H₁₇ClN₄O₂
Molecular Weight:476.922
Hs Code.:

Synonyms:(+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

There total 16 articles about (+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 892550-54-8
2-[6-chloro-9-(3-methylbut-3-en-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

: 892550-41-3
(+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Guidance literature:: 2-[6-chloro-9-(3-methylbut-3-en-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile; With water; AD-mix-α; In tert-butyl alcohol; at 0 ℃; for 24h;

With water; AD-mix-β; In tert-butyl alcohol; at 0 ℃; for 24h;

Reference yield:

: 892550-54-8
2-[6-chloro-9-(3-methylbut-3-en-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

: 75-65-0
tert-butyl alcohol

: 892550-41-3
(+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Guidance literature:: 2-[6-chloro-9-(3-methylbut-3-en-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile; tert-butyl alcohol; With (9S,9'''S)-9,9'-[1,4-phthalazinediylbis(oxy)]bis[6'-(methyloxy)-10,11-dihydrocinchonan]; In water; at 0 ℃; for 24h;

With (9S,9'''S)-9,9'-[1,4-phthalazinediylbis(oxy)]bis[6'-(methyloxy)-10,11-dihydrocinchonan]; In water; at 0 ℃; for 24h; Product distribution / selectivity;

Reference yield:

: 1193719-23-1
6-bromo-3-chlorophenanthrene-9-carboxylic acid

: 892550-41-3
(+/-)-2-[9-chloro-6-(3,4-dihydroxy-3-methylbut-1-yn-1-yl)-1H-phenanthro[9,10-d]imidazol-2-yl]isophthalonitrile

Guidance literature:: Multi-step reaction with 6 steps

1.1: chromium(VI) oxide / acetic acid / 3 h / 110 °C

2.1: ammonium acetate / acetic acid / 120 °C

3.1: N,N-dimethyl-formamide / 85 °C

4.1: triethylamine / 20% Pd(OH)2 on carbon; copper(l) iodide; triphenylphosphine / N,N-dimethyl-formamide / 17 h / 52 °C / Sealed vial

5.1: Burgess Reagent / benzene / 2 h / Heating / reflux

6.1: water / AD-mix-α / tert-butyl alcohol / 24 h / 0 °C

6.2: 24 h / 0 °C

With chromium(VI) oxide; Burgess Reagent; ammonium acetate; water; triethylamine; AD-mix-α; copper(l) iodide; 20% Pd(OH)2 on carbon; triphenylphosphine; In acetic acid; N,N-dimethyl-formamide; tert-butyl alcohol; benzene;