N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

Base Information

• Chemical Name: N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride
• CAS No.: 1293987-54-8
• Molecular Formula: C₂₄H₂₇N₇O₂S₂*ClH
• Molecular Weight: 546.117
• Mol file: 1293987-54-8.mol

Synonyms:N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

Chemical Property of N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride

There total 12 articles about N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide (1293987-05-9) → N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride (1293987-54-8)

Guidance literature:

With hydrogenchloride; In tetrahydrofuran; 1,4-dioxane; at 20 ℃; for 0.5h;

Reference yield:

4-ethylpiperazine (5308-25-8) → N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride (1293987-54-8)

Guidance literature:

Multi-step reaction with 4 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 24 h / 70 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

3: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 6 h / 120 °C

4: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 0.5 h / 20 °C

With hydrogenchloride; hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium 10% on activated carbon; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; methanol; 3: Buchwald amination;

Reference yield:

7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione (41102-02-7) → N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide hydrochloride (1293987-54-8)

Guidance literature:

Multi-step reaction with 7 steps

1: N,N-diethylaniline; trichlorophosphate / 5 h / 150 °C

2: sodium tetrahydroborate / ethanol; tetrahydrofuran / 1 h / 20 °C

3: chloranil / benzene / 3 h / Reflux

4: sodium carbonate; tert-butyl XPhos / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere

5: triethylamine / tetrahydrofuran / 2 h

6: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 6 h / 120 °C

7: hydrogenchloride / 1,4-dioxane; tetrahydrofuran / 0.5 h / 20 °C

With hydrogenchloride; sodium tetrahydroborate; chloranil; sodium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N-diethylaniline; tert-butyl XPhos; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; benzene; 4: Suzuki Coupling / 6: Buchwald amination;

upstream raw materials:

4-ethylpiperazine

1H-thieno[3,2-d]pyrimidine-2,4-dione

7-bromothieno[3,2-d]pyrimidine-2,4(1H,3H)-dione

7-bromo-2,4-dichloroimidazo[2,1-f][1,2,4]triazine