N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Base Information

Chemical Name:N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide
CAS No.:1293987-05-9
Molecular Formula:C₂₄H₂₇N₇O₂S₂
Molecular Weight:509.656
Hs Code.:

Synonyms:N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

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Chemical Property of N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

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Technology Process of N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

There total 11 articles about N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

: 295349-69-8
6-(4-ethylpiperazin-1-yl)pyridin-3-amine

: 1293987-57-1
N-(3-(2-chlorothieno[3,2-d]pyrimidin-7-yl)phenyl)-methanesulfonamide

: 1293987-05-9
N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Guidance literature:: With caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium diacetate; In 1,4-dioxane; at 120 ℃; for 6h;

Reference yield:

: 16233-51-5
1H-thieno[3,2-d]pyrimidine-2,4-dione

: 1293987-05-9
N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 7 steps

1: bromine / acetic acid / 30 h / 110 °C

2: N,N-diethylaniline; trichlorophosphate / 5 h / 150 °C

3: sodium tetrahydroborate / ethanol; tetrahydrofuran / 1 h / 20 °C

4: chloranil / benzene / 3 h / Reflux

5: sodium carbonate; tert-butyl XPhos / bis-triphenylphosphine-palladium(II) chloride / 1,4-dioxane / 6 h / 90 °C / Inert atmosphere

6: triethylamine / tetrahydrofuran / 2 h

7: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 6 h / 120 °C

With sodium tetrahydroborate; bromine; chloranil; sodium carbonate; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; N,N-diethylaniline; tert-butyl XPhos; trichlorophosphate; bis-triphenylphosphine-palladium(II) chloride; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; ethanol; acetic acid; benzene; 5: Suzuki Coupling / 7: Buchwald amination;

Reference yield:

: 5308-25-8
4-ethylpiperazine

: 1293987-05-9
N-(3-(2-(6-(4-ethylpiperazin-1-yl)pyridin-3-ylamino)thieno[3,2-d]pyrimidin-7-yl)phenyl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: N-ethyl-N,N-diisopropylamine / 1,4-dioxane / 24 h / 70 °C

2: hydrogen / palladium 10% on activated carbon / methanol / 24 h / 20 °C

3: caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene / palladium diacetate / 1,4-dioxane / 6 h / 120 °C

With hydrogen; caesium carbonate; N-ethyl-N,N-diisopropylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; palladium 10% on activated carbon; palladium diacetate; In 1,4-dioxane; methanol; 3: Buchwald amination;