(R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Base Information

Chemical Name:(R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide
CAS No.:1268368-61-1
Molecular Formula:C₁₆H₂₅NO₄S
Molecular Weight:327.445
Hs Code.:

Synonyms:(R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Suppliers and Price of (R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Chemical Property:

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Technology Process of (R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

There total 3 articles about (R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₂₂H₃₉NO₄SSi

: 1268368-61-1
(R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 0 ℃; for 16h; Inert atmosphere;
DOI:10.1021/ol200203k

Reference yield:

: 1015445-11-0
4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

: 1268368-61-1
(R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine / toluene / 0.25 h / 20 °C / Inert atmosphere

1.2: 24 h / 20 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; (1S,2R)-(+)-N-methylephedrine; tetrabutyl ammonium fluoride; zinc trifluoromethanesulfonate; triethylamine; In tetrahydrofuran; toluene;
DOI:10.1021/ol200203k

Reference yield:

: 1268368-83-7
(R)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-N-(4-hydroxy-5-methylhex-2-ynyl)-4-methylbenzenesulfonamide

: 1268368-61-1
(R,E)-N-(4-hydroxy-5-methylhex-2-enyl)-N-(2-hydroxyethyl)-4-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: lithium aluminium tetrahydride / tetrahydrofuran / 3 h / 0 °C / Inert atmosphere

2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 0 °C / Inert atmosphere

With lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1021/ol200203k