4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

Base Information

Chemical Name:4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide
CAS No.:1015445-11-0
Molecular Formula:C₁₈H₂₉NO₃SSi
Molecular Weight:367.585
Hs Code.:

Synonyms:4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

Suppliers and Price of 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

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Technology Process of 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

There total 1 articles about 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 79.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 317842-46-9
N-(2-hydroxyethyl)-4-methyl-N-(prop-2-yn-1-yl)benzenesulfonamide

: 1015445-11-0
4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;
DOI:10.1021/ol702966j

Reference yield: 92.0%

: 1015445-11-0
4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

: 78-84-2
isobutyraldehyde

: 1268368-83-7
(R)-N-(2-(tert-butyldimethylsilyloxy)ethyl)-N-(4-hydroxy-5-methylhex-2-ynyl)-4-methylbenzenesulfonamide

Guidance literature:: 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide; With (1S,2R)-(+)-N-methylephedrine; zinc trifluoromethanesulfonate; triethylamine; In toluene; at 20 ℃; for 0.25h; Inert atmosphere;

isobutyraldehyde; In toluene; at 20 ℃; for 24h; optical yield given as %ee; Inert atmosphere;
DOI:10.1021/ol200203k

Reference yield: 79.0%

: 1015445-11-0
4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide

: 123-63-7
paracetaldehyde

: 1015445-12-1
N-(4-hydroxy-2-butynyl)-4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]benzenesulfonamide

Guidance literature:: 4-methyl-N-[2-[[(1,1-dimethylethyl)dimethylsilyl]oxy]ethyl]-N-(2-propynyl)benzenesulfonamide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 1h; Inert atmosphere;

paracetaldehyde; In tetrahydrofuran; hexane; at 0 - 20 ℃; for 12h; Inert atmosphere;
DOI:10.1021/ol702966j